Analysis of the interaction between sulfonated sugars and Alzheimer Aβ

Kikuko Yasuda; Mihoko Koike; Yoshiko Miura; Kazukiyo Kobayashi

Analysis of the interaction between sulfonated sugars and Alzheimer Aβ

Kikuko Yasuda, Mihoko Koike, Yoshiko Miura, Kazukiyo Kobayashi

Research output: Contribution to conference › Paper › peer-review

Abstract

Biological active saccharide of proteoglycans and gangliosides has been reported to accelarate the amyloid formation of Alzhemir peptide. Those reports indicated the strong interaction with Ab. We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mime. Here, we investigate the interaction between sulfonated GlcNAc and Aβ42. The aggregation of Aβ with heparin and pNP 6-sulfo-GlcNAc was estimated by fluorescence of thioflavin T, CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet confomation, pNP 6-sulfo-GlcNAc inhibited them. Other saccharides like glucose and pNP GlcNAc did not show the inhibition effect.

Original language	English
Number of pages	1
Publication status	Published - Dec 1 2005
Externally published	Yes
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: May 25 2005 → May 27 2005

Other

Other	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	5/25/05 → 5/27/05

All Science Journal Classification (ASJC) codes

Engineering(all)

Cite this

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title = "Analysis of the interaction between sulfonated sugars and Alzheimer Aβ",

abstract = "Biological active saccharide of proteoglycans and gangliosides has been reported to accelarate the amyloid formation of Alzhemir peptide. Those reports indicated the strong interaction with Ab. We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mime. Here, we investigate the interaction between sulfonated GlcNAc and Aβ42. The aggregation of Aβ with heparin and pNP 6-sulfo-GlcNAc was estimated by fluorescence of thioflavin T, CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet confomation, pNP 6-sulfo-GlcNAc inhibited them. Other saccharides like glucose and pNP GlcNAc did not show the inhibition effect.",

author = "Kikuko Yasuda and Mihoko Koike and Yoshiko Miura and Kazukiyo Kobayashi",

year = "2005",

month = dec,

day = "1",

language = "English",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - Analysis of the interaction between sulfonated sugars and Alzheimer Aβ

AU - Yasuda, Kikuko

AU - Koike, Mihoko

AU - Miura, Yoshiko

AU - Kobayashi, Kazukiyo

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Biological active saccharide of proteoglycans and gangliosides has been reported to accelarate the amyloid formation of Alzhemir peptide. Those reports indicated the strong interaction with Ab. We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mime. Here, we investigate the interaction between sulfonated GlcNAc and Aβ42. The aggregation of Aβ with heparin and pNP 6-sulfo-GlcNAc was estimated by fluorescence of thioflavin T, CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet confomation, pNP 6-sulfo-GlcNAc inhibited them. Other saccharides like glucose and pNP GlcNAc did not show the inhibition effect.

AB - Biological active saccharide of proteoglycans and gangliosides has been reported to accelarate the amyloid formation of Alzhemir peptide. Those reports indicated the strong interaction with Ab. We have reported the synthesis and biological activity of sulfonated sugars for a sialic acid mime. Here, we investigate the interaction between sulfonated GlcNAc and Aβ42. The aggregation of Aβ with heparin and pNP 6-sulfo-GlcNAc was estimated by fluorescence of thioflavin T, CD spectra and TEM observations. Though heparin induced the aggregation and β-sheet confomation, pNP 6-sulfo-GlcNAc inhibited them. Other saccharides like glucose and pNP GlcNAc did not show the inhibition effect.

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UR - http://www.scopus.com/inward/citedby.url?scp=33645651406&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645651406

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Analysis of the interaction between sulfonated sugars and Alzheimer Aβ

Abstract

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All Science Journal Classification (ASJC) codes

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