Analysis of the mechanism of allograft rejection and cell-mediated immunity. II. Divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and spleen

F. Nanishi, K. Taniguchi, C. Kubo, K. Onoyama, T. Omae, K. Nomoto

Research output: Contribution to journalArticle

Abstract

CY pretreatment augmented the generation of cytotoxicity in the draining lymph node cells in mice after subcutaneous immunization with allogeneic spleen cells, or in the non-adherent peritoneal exudate cells after intraperitoneal immunization with these cells. Marginal cytotoxicity in the spleen cells after this immunization was suppressed by CY pretreatment. Similar divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and the spleen was also observed after immunization with allogeneic tumour cells which can induce high degrees of cytotoxicity without CY pretreatment. These results indicate that cytotoxic T lymphocyte (CTL) generation at the site of direct graft rejection appear to have a nature different from that related to CTL generation in the spleen. A discussion is made as to the role of CTL in the peripheral site and the spleen in cases of in vivo allograft rejection.

Original languageEnglish
Pages (from-to)23-30
Number of pages8
JournalJournal of Clinical and Laboratory Immunology
Volume12
Issue number1
Publication statusPublished - Nov 4 1983

Fingerprint

Cellular Immunity
Allografts
Spleen
Lymph Nodes
Immunization
Cytotoxic T-Lymphocytes
Graft Rejection
Exudates and Transudates
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

@article{ff2b37e7c5604de59d2f952045ff3e7b,
title = "Analysis of the mechanism of allograft rejection and cell-mediated immunity. II. Divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and spleen",
abstract = "CY pretreatment augmented the generation of cytotoxicity in the draining lymph node cells in mice after subcutaneous immunization with allogeneic spleen cells, or in the non-adherent peritoneal exudate cells after intraperitoneal immunization with these cells. Marginal cytotoxicity in the spleen cells after this immunization was suppressed by CY pretreatment. Similar divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and the spleen was also observed after immunization with allogeneic tumour cells which can induce high degrees of cytotoxicity without CY pretreatment. These results indicate that cytotoxic T lymphocyte (CTL) generation at the site of direct graft rejection appear to have a nature different from that related to CTL generation in the spleen. A discussion is made as to the role of CTL in the peripheral site and the spleen in cases of in vivo allograft rejection.",
author = "F. Nanishi and K. Taniguchi and C. Kubo and K. Onoyama and T. Omae and K. Nomoto",
year = "1983",
month = "11",
day = "4",
language = "English",
volume = "12",
pages = "23--30",
journal = "Journal of Clinical and Laboratory Immunology",
issn = "0141-2760",
publisher = "Teviot Scientific Publications Ltd.",
number = "1",

}

TY - JOUR

T1 - Analysis of the mechanism of allograft rejection and cell-mediated immunity. II. Divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and spleen

AU - Nanishi, F.

AU - Taniguchi, K.

AU - Kubo, C.

AU - Onoyama, K.

AU - Omae, T.

AU - Nomoto, K.

PY - 1983/11/4

Y1 - 1983/11/4

N2 - CY pretreatment augmented the generation of cytotoxicity in the draining lymph node cells in mice after subcutaneous immunization with allogeneic spleen cells, or in the non-adherent peritoneal exudate cells after intraperitoneal immunization with these cells. Marginal cytotoxicity in the spleen cells after this immunization was suppressed by CY pretreatment. Similar divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and the spleen was also observed after immunization with allogeneic tumour cells which can induce high degrees of cytotoxicity without CY pretreatment. These results indicate that cytotoxic T lymphocyte (CTL) generation at the site of direct graft rejection appear to have a nature different from that related to CTL generation in the spleen. A discussion is made as to the role of CTL in the peripheral site and the spleen in cases of in vivo allograft rejection.

AB - CY pretreatment augmented the generation of cytotoxicity in the draining lymph node cells in mice after subcutaneous immunization with allogeneic spleen cells, or in the non-adherent peritoneal exudate cells after intraperitoneal immunization with these cells. Marginal cytotoxicity in the spleen cells after this immunization was suppressed by CY pretreatment. Similar divergent effect of CY pretreatment on the generation of cytotoxic activity in the draining lymph nodes and the spleen was also observed after immunization with allogeneic tumour cells which can induce high degrees of cytotoxicity without CY pretreatment. These results indicate that cytotoxic T lymphocyte (CTL) generation at the site of direct graft rejection appear to have a nature different from that related to CTL generation in the spleen. A discussion is made as to the role of CTL in the peripheral site and the spleen in cases of in vivo allograft rejection.

UR - http://www.scopus.com/inward/record.url?scp=0020590903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020590903&partnerID=8YFLogxK

M3 - Article

C2 - 6631941

AN - SCOPUS:0020590903

VL - 12

SP - 23

EP - 30

JO - Journal of Clinical and Laboratory Immunology

JF - Journal of Clinical and Laboratory Immunology

SN - 0141-2760

IS - 1

ER -