Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection

A multi-institutional study of the indications for resection

Ken Shirabe, Mitsuo Shimada, Takashi Matsumata, Hidefumi Higashi, Yohichi Yakeishi, Shigeki Wakiyama, Yasuharu Ikeda, Takuhiro Ezaki, Shingo Fukuzawa, Kenji Takenaka, Keishi Kishikawa, Tetsuo Ikeda, Ken Ichi Taguchi, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Background/Aims: The number of reports of hepatic resection for metastatic gastric cancer is very small. The outcome and indications of hepatic resection for metastatic gastric cancer remains unknown. Methodology: A multi-institutional study was made. Thirty-six patients who underwent a hepatic resection for liver metastasis of gastric cancer with no residual tumor were included in this study. The clinicopathological factors were examined as prognostic factors by multivariate analyses. Thirty patients had recurrence and the recurrence pattern and risk factors for extrahepatic recurrence was examined. Results: The overall survival rate was 64% at 1 year, 43% at 2 years, 26% at 3 years 26% at 5 years, and 26% at 10 years after hepatectomy. Multivariate analysis showed that lymphatic invasion, venous invasion of cancer cells of primary gastric cancer and the number of the liver metastasis (>3) were independent poor prognostic factors after hepatic resection. The most common recurrence pattern was intrahepatic recurrence in 22 patients (73%). The risk factors for extrahepatic recurrence was serosal invasion, lymph node metastasis of primary gastric cancer, stage, and curability of operation. Conclusions: Hepatic resection for liver metastasis should be attempted in case primary gastric cancer has neither lymphatic invasion nor venous invasion. The most common recurrent site was the liver. In patients with advanced gastric cancer, having neither serosal invasion nor lymph node metastasis, who underwent a less curative operation, the intrahepatic recurrence would be expected. Thus, aggressive adjuvant chemotherapy through the hepatic artery may improve the survival after hepatectomy in these patients.

Original languageEnglish
Pages (from-to)1560-1563
Number of pages4
JournalHepato-gastroenterology
Volume50
Issue number53
Publication statusPublished - Sep 1 2003

Fingerprint

Stomach Neoplasms
Neoplasm Metastasis
Liver
Recurrence
Hepatectomy
Multivariate Analysis
Lymph Nodes
Hepatic Artery
Residual Neoplasm
Adjuvant Chemotherapy
Liver Neoplasms
Statistical Factor Analysis
Survival Rate
Survival
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Shirabe, K., Shimada, M., Matsumata, T., Higashi, H., Yakeishi, Y., Wakiyama, S., ... Sugimachi, K. (2003). Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection: A multi-institutional study of the indications for resection. Hepato-gastroenterology, 50(53), 1560-1563.

Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection : A multi-institutional study of the indications for resection. / Shirabe, Ken; Shimada, Mitsuo; Matsumata, Takashi; Higashi, Hidefumi; Yakeishi, Yohichi; Wakiyama, Shigeki; Ikeda, Yasuharu; Ezaki, Takuhiro; Fukuzawa, Shingo; Takenaka, Kenji; Kishikawa, Keishi; Ikeda, Tetsuo; Taguchi, Ken Ichi; Maehara, Yoshihiko; Sugimachi, Keizo.

In: Hepato-gastroenterology, Vol. 50, No. 53, 01.09.2003, p. 1560-1563.

Research output: Contribution to journalArticle

Shirabe, K, Shimada, M, Matsumata, T, Higashi, H, Yakeishi, Y, Wakiyama, S, Ikeda, Y, Ezaki, T, Fukuzawa, S, Takenaka, K, Kishikawa, K, Ikeda, T, Taguchi, KI, Maehara, Y & Sugimachi, K 2003, 'Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection: A multi-institutional study of the indications for resection', Hepato-gastroenterology, vol. 50, no. 53, pp. 1560-1563.
Shirabe, Ken ; Shimada, Mitsuo ; Matsumata, Takashi ; Higashi, Hidefumi ; Yakeishi, Yohichi ; Wakiyama, Shigeki ; Ikeda, Yasuharu ; Ezaki, Takuhiro ; Fukuzawa, Shingo ; Takenaka, Kenji ; Kishikawa, Keishi ; Ikeda, Tetsuo ; Taguchi, Ken Ichi ; Maehara, Yoshihiko ; Sugimachi, Keizo. / Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection : A multi-institutional study of the indications for resection. In: Hepato-gastroenterology. 2003 ; Vol. 50, No. 53. pp. 1560-1563.
@article{7c57a2cb05414f8cb91fbd6ab6d14850,
title = "Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection: A multi-institutional study of the indications for resection",
abstract = "Background/Aims: The number of reports of hepatic resection for metastatic gastric cancer is very small. The outcome and indications of hepatic resection for metastatic gastric cancer remains unknown. Methodology: A multi-institutional study was made. Thirty-six patients who underwent a hepatic resection for liver metastasis of gastric cancer with no residual tumor were included in this study. The clinicopathological factors were examined as prognostic factors by multivariate analyses. Thirty patients had recurrence and the recurrence pattern and risk factors for extrahepatic recurrence was examined. Results: The overall survival rate was 64{\%} at 1 year, 43{\%} at 2 years, 26{\%} at 3 years 26{\%} at 5 years, and 26{\%} at 10 years after hepatectomy. Multivariate analysis showed that lymphatic invasion, venous invasion of cancer cells of primary gastric cancer and the number of the liver metastasis (>3) were independent poor prognostic factors after hepatic resection. The most common recurrence pattern was intrahepatic recurrence in 22 patients (73{\%}). The risk factors for extrahepatic recurrence was serosal invasion, lymph node metastasis of primary gastric cancer, stage, and curability of operation. Conclusions: Hepatic resection for liver metastasis should be attempted in case primary gastric cancer has neither lymphatic invasion nor venous invasion. The most common recurrent site was the liver. In patients with advanced gastric cancer, having neither serosal invasion nor lymph node metastasis, who underwent a less curative operation, the intrahepatic recurrence would be expected. Thus, aggressive adjuvant chemotherapy through the hepatic artery may improve the survival after hepatectomy in these patients.",
author = "Ken Shirabe and Mitsuo Shimada and Takashi Matsumata and Hidefumi Higashi and Yohichi Yakeishi and Shigeki Wakiyama and Yasuharu Ikeda and Takuhiro Ezaki and Shingo Fukuzawa and Kenji Takenaka and Keishi Kishikawa and Tetsuo Ikeda and Taguchi, {Ken Ichi} and Yoshihiko Maehara and Keizo Sugimachi",
year = "2003",
month = "9",
day = "1",
language = "English",
volume = "50",
pages = "1560--1563",
journal = "Acta hepato-splenologica",
issn = "0172-6390",
publisher = "H.G.E. Update Medical Publishing Ltd.",
number = "53",

}

TY - JOUR

T1 - Analysis of the prognostic factors for liver metastasis of gastric cancer after hepatic resection

T2 - A multi-institutional study of the indications for resection

AU - Shirabe, Ken

AU - Shimada, Mitsuo

AU - Matsumata, Takashi

AU - Higashi, Hidefumi

AU - Yakeishi, Yohichi

AU - Wakiyama, Shigeki

AU - Ikeda, Yasuharu

AU - Ezaki, Takuhiro

AU - Fukuzawa, Shingo

AU - Takenaka, Kenji

AU - Kishikawa, Keishi

AU - Ikeda, Tetsuo

AU - Taguchi, Ken Ichi

AU - Maehara, Yoshihiko

AU - Sugimachi, Keizo

PY - 2003/9/1

Y1 - 2003/9/1

N2 - Background/Aims: The number of reports of hepatic resection for metastatic gastric cancer is very small. The outcome and indications of hepatic resection for metastatic gastric cancer remains unknown. Methodology: A multi-institutional study was made. Thirty-six patients who underwent a hepatic resection for liver metastasis of gastric cancer with no residual tumor were included in this study. The clinicopathological factors were examined as prognostic factors by multivariate analyses. Thirty patients had recurrence and the recurrence pattern and risk factors for extrahepatic recurrence was examined. Results: The overall survival rate was 64% at 1 year, 43% at 2 years, 26% at 3 years 26% at 5 years, and 26% at 10 years after hepatectomy. Multivariate analysis showed that lymphatic invasion, venous invasion of cancer cells of primary gastric cancer and the number of the liver metastasis (>3) were independent poor prognostic factors after hepatic resection. The most common recurrence pattern was intrahepatic recurrence in 22 patients (73%). The risk factors for extrahepatic recurrence was serosal invasion, lymph node metastasis of primary gastric cancer, stage, and curability of operation. Conclusions: Hepatic resection for liver metastasis should be attempted in case primary gastric cancer has neither lymphatic invasion nor venous invasion. The most common recurrent site was the liver. In patients with advanced gastric cancer, having neither serosal invasion nor lymph node metastasis, who underwent a less curative operation, the intrahepatic recurrence would be expected. Thus, aggressive adjuvant chemotherapy through the hepatic artery may improve the survival after hepatectomy in these patients.

AB - Background/Aims: The number of reports of hepatic resection for metastatic gastric cancer is very small. The outcome and indications of hepatic resection for metastatic gastric cancer remains unknown. Methodology: A multi-institutional study was made. Thirty-six patients who underwent a hepatic resection for liver metastasis of gastric cancer with no residual tumor were included in this study. The clinicopathological factors were examined as prognostic factors by multivariate analyses. Thirty patients had recurrence and the recurrence pattern and risk factors for extrahepatic recurrence was examined. Results: The overall survival rate was 64% at 1 year, 43% at 2 years, 26% at 3 years 26% at 5 years, and 26% at 10 years after hepatectomy. Multivariate analysis showed that lymphatic invasion, venous invasion of cancer cells of primary gastric cancer and the number of the liver metastasis (>3) were independent poor prognostic factors after hepatic resection. The most common recurrence pattern was intrahepatic recurrence in 22 patients (73%). The risk factors for extrahepatic recurrence was serosal invasion, lymph node metastasis of primary gastric cancer, stage, and curability of operation. Conclusions: Hepatic resection for liver metastasis should be attempted in case primary gastric cancer has neither lymphatic invasion nor venous invasion. The most common recurrent site was the liver. In patients with advanced gastric cancer, having neither serosal invasion nor lymph node metastasis, who underwent a less curative operation, the intrahepatic recurrence would be expected. Thus, aggressive adjuvant chemotherapy through the hepatic artery may improve the survival after hepatectomy in these patients.

UR - http://www.scopus.com/inward/record.url?scp=10744232399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10744232399&partnerID=8YFLogxK

M3 - Article

VL - 50

SP - 1560

EP - 1563

JO - Acta hepato-splenologica

JF - Acta hepato-splenologica

SN - 0172-6390

IS - 53

ER -