Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen

K. Honda, K. Makishima, T. Sasazuki

Research output: Contribution to journalArticle

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Abstract

Genetic control of the immune response to Cryptomeria japonica pollen antigen (CPAg) in humans was analyzed using 72 unrelated healthy adults. The 72 were classified into a low responder group and a high responder group by using purified CPAg. Significant associations were found between IgG low responsiveness to purified CPAg and possession of HLA-DQw3. Relative risks for the two groups were 4.80. Peripheral blood lymphocytes from low responders revealed a specific IgG response to CPAg when the CD8+ T cell fraction was depleted. Thereby, low response due to the presence of CPAg-specific CD8+ suppressor T cells was suggested.

Original languageEnglish
Pages (from-to)423-427
Number of pages5
JournalArerugī = [Allergy]
Volume40
Issue number4
Publication statusPublished - Apr 1991

Fingerprint

Cryptomeria
Pollen
Immunoglobulin G
Antigens
CD8 Antigens
T-Lymphocytes
Lymphocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Honda, K., Makishima, K., & Sasazuki, T. (1991). Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen. Arerugī = [Allergy], 40(4), 423-427.

Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen. / Honda, K.; Makishima, K.; Sasazuki, T.

In: Arerugī = [Allergy], Vol. 40, No. 4, 04.1991, p. 423-427.

Research output: Contribution to journalArticle

Honda, K, Makishima, K & Sasazuki, T 1991, 'Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen', Arerugī = [Allergy], vol. 40, no. 4, pp. 423-427.
Honda, K. ; Makishima, K. ; Sasazuki, T. / Analysis of the regulation of IgG production to Cryptomeria japonica pollen antigen. In: Arerugī = [Allergy]. 1991 ; Vol. 40, No. 4. pp. 423-427.
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