Analysis of tumor necrosis factor-α gene promoter polymorphisms in anorexia nervosa

Tetsuya Ando, Toshio Ishikawa, Noriyuki Kawamura, Masami Karibe, Mariko Oba, Naoko Tatsuta, Shinichiro Hara, Masato Takii, Tetsuo Naruo, Michiko Takei, Nobuo Kurokawa, Shinichi Nozoe, Chiharu Kubo, Gen Komaki

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21 Citations (Scopus)

Abstract

Elevated plasma tumor necrosis factor-α (TNFα) levels and enhanced spontaneous TNFα release from peripheral blood mononuclear cells in patients with anorexia nervosa (AN) have been reported. TNFα activates the hypothalamic-pituitary-adrenal axis and reduces food intake, which is characteristic of eating disorders. Recently, three novel polymorphisms in the 5′-flanking region of the TNFα gene were reported at positions -1031(T → C substitution), -863 (C → A) and -857 (C → T). Differences in these alleles are reportedly related to altered TNFα-transcriptional promoter activity. Therefore, we performed a case-control association analysis to determine whether any of those three polymorphisms in the TNFα promoter region were involved in a predisposition to AN. The results of our analysis of a cohort of 79 female Japanese AN sufferers and 127 normal female control subjects provide no support for the hypothesis that -1031T/C, -863 C /A and -857C/T polymorphisms in the TNFα gene promoter region influence the susceptibility to AN.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalPsychiatric Genetics
Volume11
Issue number3
DOIs
Publication statusPublished - Oct 30 2001

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry

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    Ando, T., Ishikawa, T., Kawamura, N., Karibe, M., Oba, M., Tatsuta, N., Hara, S., Takii, M., Naruo, T., Takei, M., Kurokawa, N., Nozoe, S., Kubo, C., & Komaki, G. (2001). Analysis of tumor necrosis factor-α gene promoter polymorphisms in anorexia nervosa. Psychiatric Genetics, 11(3), 161-164. https://doi.org/10.1097/00041444-200109000-00009