Angina pectoris occurring during granulocyte colony-stimulating factor- combined preparatory regimen for autologous peripheral blood stem cell transplantation in a patient with acute myelogenous leukaemia

Yumiko Fukumoto, Toshihiro Miyamoto, Takashi Okamura, Hisashi Gondo, Hiromi Iwasaki, Takahiko Horiuchi, Shigeru Yoshizawa, Shoichi Inaba, Mine Harada, Yoshiyuki Niho

Research output: Contribution to journalArticlepeer-review

57 Citations (Scopus)

Abstract

We describe a patient with acute myelogenous leukaemia who developed angina pectoris during pretransplant conditioning for autologous peripheral blood stem cell transplantation (PBSCT): the conditioning regimen consisted of cytotoxic drugs in combination with granulocyte colony-stimulating factor (G-CSF). Neutrophilia and hyper-coagulability were observed at the time of angina pectoris. Recurrence of angina pectoris was not seen after nitrate and aspirin therapy. Exercise stress testing performed after PBSCT suggested the presence of myocardial ischaemia. Therefore cases at risk of vascular events should be carefully managed with prophylactic treatment during G-CSF administration.

Original languageEnglish
Pages (from-to)666-668
Number of pages3
JournalBritish Journal of Haematology
Volume97
Issue number3
DOIs
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Hematology

Fingerprint Dive into the research topics of 'Angina pectoris occurring during granulocyte colony-stimulating factor- combined preparatory regimen for autologous peripheral blood stem cell transplantation in a patient with acute myelogenous leukaemia'. Together they form a unique fingerprint.

Cite this