Angiogenesis as a target for gastric cancer

Yoshihiro Kakeji, Yoshihiko Maehara, Yasushi Sumiyoshi, Shinya Oda, Yasunori Emi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. The growth of solid tumors and the formation of metastases depend on angiogenesis. Both tumor cells and host cells secrete a variety of factors to stimulate angiogenesis. Methods. We investigated the expression of angiogenic factors in gastric cancer in vitro and in vivo. Results. The expression of one of the angiogenic factors, vascular endothelial growth factor antigen, in gastric cancer cells can thus serve as a pertinent predictive factor for hematogenous invasion or metastasis, in addition to having prognostic value. The presence of micrometastasis in bone marrow was closely related to vascular endothelial growth factor positivity and microvessel density in the primary gastric cancer. In in vivo experiments antiangiogenic agents with cytotoxic anticancer drugs formed a highly effective modulator combination for the treatment of the Lewis lung carcinoma against primary and metastatic disease. Conclusions. Antiangiogenic agents may thus be valuable for long-term administration to maintain tumor dormancy because drug resistance does not develop, and these agents have a sustained effect. As a target, antiangiogenic therapy may therefore be potentially able to prolong survival time of patients with gastric cancer.

Original languageEnglish
Pages (from-to)S48-S54
JournalSurgery
Volume131
Issue number1 SUPPL.
DOIs
Publication statusPublished - Jan 1 2002

All Science Journal Classification (ASJC) codes

  • Surgery

Fingerprint Dive into the research topics of 'Angiogenesis as a target for gastric cancer'. Together they form a unique fingerprint.

  • Cite this

    Kakeji, Y., Maehara, Y., Sumiyoshi, Y., Oda, S., & Emi, Y. (2002). Angiogenesis as a target for gastric cancer. Surgery, 131(1 SUPPL.), S48-S54. https://doi.org/10.1067/msy.2002.119304