TY - GEN
T1 - Angiogenesis derived from shear stress optimised by a microfruidic device
AU - Teraoka, Yukako
AU - Nakayama, Masamune
AU - Nashimoto, Yuji
AU - Nakamasu, Akiko
AU - Hanada, Sanshiro
AU - Arima, Yuichiro
AU - Torisawa, Yu Suke
AU - Kotera, Hidetoshi
AU - Nishiyama, Koichi
AU - Miura, Takashi
AU - Yokokawa, Ryuji
N1 - Funding Information:
This work was supported by CREST, Japan Science and Technology Agency (JST).
PY - 2020
Y1 - 2020
N2 - Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.
AB - Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.
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M3 - Conference contribution
AN - SCOPUS:85079684820
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 1072
EP - 1073
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -