Abstract
Previously, we created a 3D vascular network in a microfluidic device and demonstrated that the luminal flow significantly enhanced the formation of angiogenic sprouts as compared to static conditions [1]. These results could not be explained based on either biochemical factors (oxygen and nutrient transport) or mechanical factors (pressure and shear stress) derived angiogenesis. In this study, we investigated the effect of flow rate and shear stress on angiogenesis induced by luminal flow. We calculated the shear stress exposed on the endothelium where new sprouting initiated. Our results showed that angiogenesis was induced in the specific range of shear stress.
| Original language | English |
|---|---|
| Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1072-1073 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780692941836 |
| Publication status | Published - Jan 1 2020 |
| Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017 |
Publication series
| Name | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|
Conference
| Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|---|
| Country | United States |
| City | Savannah |
| Period | 10/22/17 → 10/26/17 |
All Science Journal Classification (ASJC) codes
- Chemical Engineering (miscellaneous)
- Bioengineering
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Cite this
Teraoka, Y., Nakayama, M., Nashimoto, Y., Nakamasu, A., Hanada, S., Arima, Y., Torisawa, Y. S., Kotera, H., Nishiyama, K., Miura, T., & Yokokawa, R. (2020). Angiogenesis derived from shear stress optimised by a microfruidic device. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1072-1073). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.