Angiogenic and lymphangiogenic cascades in the tumor microenvironment

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Blood and lymphatic vessels in tumor tissue are major components of the tumor microenvironment. These vessels are newly formed from pre-existing host vessels stimulated by pro-blood-angiogenic and pro-lymphangiogenic (pro-blood/lymph-angiogenic) factors expressed in tumor cells. Tumor cells establish a specific stromal microenvironment fostering tumor growth, in which blood/lymph-angiogenesis are involved. The tumorassociated blood/lymph- angiogenesis is continually induced by complicated cytokine networks, namely problood/ lymph-angiogenic factor-mediated paracrine and autocrine interactions among tumor cells and stromal cells including endothelial cells (ECs) and non-endothelial mesenchymal cells (neMCs). In this review, we provide an overview of the features of tumor-associated blood/lymphangiogenesis based on recent and updated information obtained mainly from our studies. With regard to the constituent cell-dependent molecular mechanisms that regulate tumor blood/lymph-angiogenesis, we focus on: 1) the role of blood/lymph-angiogenesis- related factors/receptors expressed in tumor cells; and 2) the role of blood/lymph-angiogenesis-related factors/receptors expressed in stromal cells (ECs and neMCs). Finally, we discuss the features of tumor-associated blood/lymphanigogenesis, especially a vessel abnormality through the viewpoint of blood/lymph-angiogenic cascades in tumor microenvironment for better understanding of the tumor vascular biology.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number1
Publication statusPublished - Jan 1 2011

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Tumor Microenvironment
Tumors
Lymph
Blood
Angiogenesis Inducing Agents
Neoplasms
Cells
Stromal Cells
Endothelial cells
Blood Vessels
Lymphatic Vessel Tumors
Endothelial Cells
Lymphangiogenesis
Foster Home Care
Cytokines

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Angiogenic and lymphangiogenic cascades in the tumor microenvironment. / Onimaru, Mitsuho; Yonemitsu, Yoshikazu.

In: Frontiers in Bioscience - Scholar, Vol. 3 S, No. 1, 01.01.2011, p. 216-225.

Research output: Contribution to journalArticle

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