Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: The Hisayama study

Yasufumi Doi, Toshiharu Ninomiya, Yoichiro Hirakawa, Otowa Takahashi, Naoko Mukai, Jun Hata, Masanori Iwase, Takanari Kitazono, Yuichi Oike, Yutaka Kiyohara

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

OBJECTIVE - To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS - A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: >2.15, 2.16-2.71, 2.72-3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM. RESULTS - In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONS - Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalDiabetes care
Volume36
Issue number1
DOIs
Publication statusPublished - Jan 1 2013

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Angiopoietins
C-Reactive Protein
Type 2 Diabetes Mellitus
Independent Living
Serum
Population
Proteins
Research Design
Multivariate Analysis
Cytokines

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population : The Hisayama study. / Doi, Yasufumi; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Takahashi, Otowa; Mukai, Naoko; Hata, Jun; Iwase, Masanori; Kitazono, Takanari; Oike, Yuichi; Kiyohara, Yutaka.

In: Diabetes care, Vol. 36, No. 1, 01.01.2013, p. 98-100.

Research output: Contribution to journalArticle

Doi, Yasufumi ; Ninomiya, Toshiharu ; Hirakawa, Yoichiro ; Takahashi, Otowa ; Mukai, Naoko ; Hata, Jun ; Iwase, Masanori ; Kitazono, Takanari ; Oike, Yuichi ; Kiyohara, Yutaka. / Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population : The Hisayama study. In: Diabetes care. 2013 ; Vol. 36, No. 1. pp. 98-100.
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