TY - JOUR
T1 - Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population
T2 - The Hisayama study
AU - Doi, Yasufumi
AU - Ninomiya, Toshiharu
AU - Hirakawa, Yoichiro
AU - Takahashi, Otowa
AU - Mukai, Naoko
AU - Hata, Jun
AU - Iwase, Masanori
AU - Kitazono, Takanari
AU - Oike, Yuichi
AU - Kiyohara, Yutaka
PY - 2013/1
Y1 - 2013/1
N2 - OBJECTIVE - To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS - A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: >2.15, 2.16-2.71, 2.72-3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM. RESULTS - In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONS - Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.
AB - OBJECTIVE - To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS - A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: >2.15, 2.16-2.71, 2.72-3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM. RESULTS - In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONS - Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.
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U2 - 10.2337/dc12-0166
DO - 10.2337/dc12-0166
M3 - Article
C2 - 22966088
AN - SCOPUS:84872012318
VL - 36
SP - 98
EP - 100
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 1
ER -
