Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: The Hisayama Study

Tomoko Usui, Toshiharu Ninomiya, Masaharu Nagata, Otowa Takahashi, Yasufumi Doi, Jun Hata, Masayo Fukuhara, Takanari Kitazono, Yuichi Oike, Yutaka Kiyohara

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). Methods and Results: A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR <60 ml · min-1 · 1.73 m-2). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95% CI: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95% CI: 1.32-2.39; ≥3.66 ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.

Original languageEnglish
Pages (from-to)2311-2317
Number of pages7
JournalCirculation Journal
Volume77
Issue number9
DOIs
Publication statusPublished - Aug 28 2013

Fingerprint

Angiopoietins
Chronic Renal Insufficiency
Odds Ratio
Population
Proteins
Confidence Intervals
Serum
Albuminuria
Logistic Models
Independent Living
Adipokines
Glomerular Filtration Rate
Albumins
Creatinine
Urine
Inflammation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population : The Hisayama Study. / Usui, Tomoko; Ninomiya, Toshiharu; Nagata, Masaharu; Takahashi, Otowa; Doi, Yasufumi; Hata, Jun; Fukuhara, Masayo; Kitazono, Takanari; Oike, Yuichi; Kiyohara, Yutaka.

In: Circulation Journal, Vol. 77, No. 9, 28.08.2013, p. 2311-2317.

Research output: Contribution to journalArticle

Usui, Tomoko ; Ninomiya, Toshiharu ; Nagata, Masaharu ; Takahashi, Otowa ; Doi, Yasufumi ; Hata, Jun ; Fukuhara, Masayo ; Kitazono, Takanari ; Oike, Yuichi ; Kiyohara, Yutaka. / Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population : The Hisayama Study. In: Circulation Journal. 2013 ; Vol. 77, No. 9. pp. 2311-2317.
@article{ed1dbc00d64c4ab8804784beeccf7eb4,
title = "Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: The Hisayama Study",
abstract = "Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). Methods and Results: A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR <60 ml · min-1 · 1.73 m-2). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5{\%}. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95{\%} confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95{\%} CI: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95{\%} CI: 1.32-2.39; ≥3.66 ng/ml: OR, 1.79, 95{\%} CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.",
author = "Tomoko Usui and Toshiharu Ninomiya and Masaharu Nagata and Otowa Takahashi and Yasufumi Doi and Jun Hata and Masayo Fukuhara and Takanari Kitazono and Yuichi Oike and Yutaka Kiyohara",
year = "2013",
month = "8",
day = "28",
doi = "10.1253/circj.CJ-12-1548",
language = "English",
volume = "77",
pages = "2311--2317",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "9",

}

TY - JOUR

T1 - Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population

T2 - The Hisayama Study

AU - Usui, Tomoko

AU - Ninomiya, Toshiharu

AU - Nagata, Masaharu

AU - Takahashi, Otowa

AU - Doi, Yasufumi

AU - Hata, Jun

AU - Fukuhara, Masayo

AU - Kitazono, Takanari

AU - Oike, Yuichi

AU - Kiyohara, Yutaka

PY - 2013/8/28

Y1 - 2013/8/28

N2 - Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). Methods and Results: A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR <60 ml · min-1 · 1.73 m-2). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95% CI: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95% CI: 1.32-2.39; ≥3.66 ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.

AB - Background: Angiopoietin-like protein 2 (Angptl2) is an adipokine that promotes inflammation and endothelial dysfunction of the vessels. The aim of this study was to investigate the relationship between serum Angptl2 level and chronic kidney disease (CKD). Methods and Results: A total of 3,169 community-dwelling subjects aged ≥40 years were divided into quintiles by Angptl2 level. CKD was defined as the presence of albuminuria (urine albumin-creatinine ratio ≥30.0 mg/g) or decreased estimated glomerular filtration rate (eGFR <60 ml · min-1 · 1.73 m-2). The odds ratio (OR) for the presence of CKD was calculated using a logistic regression model. The overall prevalence of CKD was 37.5%. The age- and sex-adjusted ORs for the presence of CKD increased with higher serum Angptl2 level. This trend remained significant after adjusting for known cardiovascular risk factors (<2.01 ng/ml: OR, 1.00 (reference); 2.01-2.48 ng/ml: OR, 1.67, 95% confidence interval [CI]: 1.24-2.24; 2.49-2.99 ng/ml: OR, 1.70, 95% CI: 1.27-2.28; 3.00-3.65 ng/ml: OR, 1.78, 95% CI: 1.32-2.39; ≥3.66 ng/ml: OR, 1.79, 95% CI: 1.32-2.43; P-value for trend=0.001). Multivariate-adjusted ORs for the presence of albuminuria increased significantly with elevated serum Angptl2 (P-value for trend=0.004), while there was no evidence of a significant relationship between serum Angptl2 level and decreased eGFR (P-value for trend=0.08). Conclusions: Elevated serum Angptl2 is associated with the likelihood of CKD in the general population.

UR - http://www.scopus.com/inward/record.url?scp=84882773029&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882773029&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-12-1548

DO - 10.1253/circj.CJ-12-1548

M3 - Article

C2 - 23739531

AN - SCOPUS:84882773029

VL - 77

SP - 2311

EP - 2317

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 9

ER -