Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

Masakazu Kawajiri, M. Mogi, N. Higaki, T. Matsuoka, Y. Ohyagi, K. Tsukuda, K. Kohara, M. Horiuchi, T. Miki, J. I. Kira

Research output: Contribution to journalArticle

29 Citations (Scopus)


Background: We reported a reduction in the levels of angiotensin II in cerebrospinal fluid (CSF) from patients with multiple sclerosis (MS). Objective and methods: To clarify the mechanism underlying this reduction, we assayed angiotensin-converting enzyme (ACE) and ACE2 concentrations along with angiotensin II concentrations in CSF samples from 20 patients with MS and 17 controls with non-neurological diseases. Results: ACE levels were significantly elevated in patients with MS compared with controls (48.42 ± 4.84 vs 44.71 ± 3.9 pg/ mL), whereas ACE2 levels were significantly reduced (2.56 ± 0.26 vs 2.78 ± 0.24 pg/mL), acting toward a normalization of angiotensin II levels. Conclusion: These results further indicate an alteration of the intrathecal renin-angiotensin system in patients with MS.

Original languageEnglish
Pages (from-to)262-265
Number of pages4
JournalMultiple Sclerosis
Issue number2
Publication statusPublished - Feb 9 2009


All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this