Angiotensin-converting enzyme gene polymorphism in Nepal

S. Umemura, T. Kawasaki, T. Ishigami, T. Fujita, K. Hibi, M. Kawasaki, K. Itoh, Y. Yoshimizu, Tetsuro Ogaki, G. P. Acharya, M. Ishii

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Abstract

It has recently been found that there were very few hypertensives in the inhabitants of one Nepalese village, even though their salt consumption, per capita, was as high as citizens in many western countries. To evaluate the genetic factors involved in this phenomenon, we studied whether they had a special genotype distribution of angiotensin-converting enzyme (ACE) gene I/D polymorphism, which was recently reported to be involved in salt sensitivity. One hundred and thirty-eight subjects were evaluated in Nepal. Only nine subjects (6.5%) in this population were hypertensives (over 140/90 mm Hg) while consuming 11 g salt/day, which confirmed the previous results. The distribution of genotypes and alleles of ACE gene I/D polymorphism was similar to that in the Japanese and Chinese, who had five-times more hypertensives while consuming almost as much salt as Nepalese, but significantly different from those in Caucasians. The present study reports, for the first time, the genotype distribution of ACE gene I/D polymorphism in Nepalese subjects. Furthermore, the results suggest ACE gene polymorphism may not be involved in the 'salt-resistance' in this population.

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalJournal of human hypertension
Volume12
Issue number8
DOIs
Publication statusPublished - Jan 1 1998

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Nepal
Peptidyl-Dipeptidase A
Salts
Genes
Genotype
Population
Alleles

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Umemura, S., Kawasaki, T., Ishigami, T., Fujita, T., Hibi, K., Kawasaki, M., ... Ishii, M. (1998). Angiotensin-converting enzyme gene polymorphism in Nepal. Journal of human hypertension, 12(8), 527-531. https://doi.org/10.1038/sj.jhh.1000655

Angiotensin-converting enzyme gene polymorphism in Nepal. / Umemura, S.; Kawasaki, T.; Ishigami, T.; Fujita, T.; Hibi, K.; Kawasaki, M.; Itoh, K.; Yoshimizu, Y.; Ogaki, Tetsuro; Acharya, G. P.; Ishii, M.

In: Journal of human hypertension, Vol. 12, No. 8, 01.01.1998, p. 527-531.

Research output: Contribution to journalArticle

Umemura, S, Kawasaki, T, Ishigami, T, Fujita, T, Hibi, K, Kawasaki, M, Itoh, K, Yoshimizu, Y, Ogaki, T, Acharya, GP & Ishii, M 1998, 'Angiotensin-converting enzyme gene polymorphism in Nepal', Journal of human hypertension, vol. 12, no. 8, pp. 527-531. https://doi.org/10.1038/sj.jhh.1000655
Umemura S, Kawasaki T, Ishigami T, Fujita T, Hibi K, Kawasaki M et al. Angiotensin-converting enzyme gene polymorphism in Nepal. Journal of human hypertension. 1998 Jan 1;12(8):527-531. https://doi.org/10.1038/sj.jhh.1000655
Umemura, S. ; Kawasaki, T. ; Ishigami, T. ; Fujita, T. ; Hibi, K. ; Kawasaki, M. ; Itoh, K. ; Yoshimizu, Y. ; Ogaki, Tetsuro ; Acharya, G. P. ; Ishii, M. / Angiotensin-converting enzyme gene polymorphism in Nepal. In: Journal of human hypertension. 1998 ; Vol. 12, No. 8. pp. 527-531.
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