Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients

Naotsugu Oyama, Kazushi Urasawa, Satoshi Kaneta, Hidetsugu Sakai, Takahiko Saito, Chika Takagi, Ichiro Yoshida, Akira Kitabatake, Hiroyuki Tsutsui

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: There are few biological markers, which strictly show the severity of congestive heart failure (CHF). Methods and Results: Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting enzyme inhibitor (ACEI) (IIA), 5 patients in class-II without ACEI (IIC), and 5 patients in class-III treated with ACEI (IIIA). GRK mRNA level in IIIA was significantly higher than those in IIA (p<0.05). GRK mRNA level in IIA were significantly lower than those in IIC (p<0.05). Conclusions: The expression level of lymphocyte GRK might show the severity of CHF, and ACEI treatment could reduce the level of GRK in CHF patients.

Original languageEnglish
Pages (from-to)362-363
Number of pages2
JournalCirculation Journal
Volume70
Issue number3
DOIs
Publication statusPublished - Mar 7 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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