Angiotensin II attenuates vascular contractility in the rabbit mesenteric artery

Masahiro Oike, Naotsugu Takahashi, Yushi Ito

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Abstract

We observed the effects of angiotensin II (AII) on the contractile response and the Ca2+ transient induced by high K+ solution in the rabbit mesenteric artery. In the control condition, the repented application of high K+ solution with 90 min interval induced a gradually increasing contraction, which was accompanied with a significant elevation of the intracellular calcium concentration ([Ca2+](i)). Treatment of the tissue with AII for one to two hours abolished the incremental response of the contraction. The change in [Ca2+](i) induced by high K+ solution, however, was not significantly different with and without treatment with AII. Pretreatment of the tissue with actinomycin D abolished the inhibitory action of AII on the incremental contraction, indicating the involvement of a transcriptional process. These results indicate that AII impairs vascular contractility through the modulation of Ca2+-sensitivity of the contractile machinery.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume222
Issue number2
DOIs
Publication statusPublished - May 15 1996

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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