Animal models for retinitis pigmentosa induced by MNU; disease progression, mechanisms and therapeutic trials

A. Tsubura, K. Yoshizawa, M. Kuwata, N. Uehara

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

Retinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases in humans characterized by loss of photoreceptor cells leading to visual disturbance and eventually to blindness. A single systemic administration of N-methyl-N-nitrosourea (MNU) causes retinal degeneration in various animal species. The retinal degeneration is highly reproducible, and the photoreceptor cell loss occurs within seven days after MNU administration via apoptosis resembling human RP. Here, we describe the disease progression, disease mechanisms, and therapeutic trials of MNUinduced retinal degeneration.

Original languageEnglish
Pages (from-to)933-944
Number of pages12
JournalHistology and histopathology
Volume25
Issue number7
Publication statusPublished - Jul 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology

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