Animal models for steroid-induced osteonecrosis

Takuaki Yamamoto, Keita Miyanishi, goro motomura, Kenjiro Nishida, Yukihide Iwamoto, Katsuo Sueishi

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)


We describe that high-dose methylprednisolone (20 mg/kg) can induce multifocal osteonecrosis (ON) in conjunction with thrombocytopenia, hypofibrinogenemia, and hyperlipemia. Detailed clinical and laboratory evaluations of coagulation system are recommended in those patients who develop manifestations of an abnormal lipid metabolism shortly after high-dose corticosteroid therapy. Moreover, we investigated the effects of the combination treatment with an anticoagulant (warfarin) plus a lipid-lowering agent (probucol) on prevention of steroid-induced osteonecrosis (ON) in this animal model. The incidence of ON in warfarin plus probucol (5%) was significantly lower than that observed in the control group (70%) (p <0.0001). Our results experimentally showed that the combined use of an anticoagulant and a lipid-lowering agent helps prevent steroid-induced ON in rabbits.

Original languageEnglish
Pages (from-to)879-886
Number of pages8
JournalClinical calcium
Issue number6
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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