Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids

Mitsuru Shindo, Kotaro Itoh, Chinatsu Tsuchiya, Kozo Shishido

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

(Equation Presented) The inverse electron-demand 1,3-dipolar cycloaddition of nitrones with ynolates, followed by quenching with t-BuOH, produced substituted 5-isoxazolidinones with good trans-selectivity. These products were easily converted into β-amino acids.

Original languageEnglish
Pages (from-to)3119-3121
Number of pages3
JournalOrganic Letters
Volume4
Issue number18
DOIs
Publication statusPublished - Sep 5 2002
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Anionic Inverse Electron-Demand 1,3-Dipolar Cycloaddition of Nitrones with Ynolates. Facile Stereoselective Synthesis of 5-Isoxazolidinones Leading to β-Amino Acids'. Together they form a unique fingerprint.

Cite this