Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis

collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI)

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and aims: The ankle–brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. Methods: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality. Results: During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95% confidence interval [CI] 0.91–1.27) for ABI of 1.00–1.09, HR 1.37 (95% CI 1.04–1.81) for ABI of 0.91–0.99, and HR 1.60 (95% CI 1.06–2.41) for ABI of ≤0.90, compared with ABI of 1.10–1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95% CI 1.14–5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome. Conclusions: The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.

Original languageEnglish
Pages (from-to)141-148
Number of pages8
JournalAtherosclerosis
Volume275
DOIs
Publication statusPublished - Aug 2018

Fingerprint

Oscillometry
Ankle Brachial Index
Premature Mortality
Meta-Analysis
Cardiovascular Diseases
Confidence Intervals
Population
Mortality
Independent Living

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI) (2018). Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Atherosclerosis, 275, 141-148. https://doi.org/10.1016/j.atherosclerosis.2018.05.048

Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population : An individual participant data meta-analysis. / collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI).

In: Atherosclerosis, Vol. 275, 08.2018, p. 141-148.

Research output: Contribution to journalArticle

collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI) 2018, 'Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis', Atherosclerosis, vol. 275, pp. 141-148. https://doi.org/10.1016/j.atherosclerosis.2018.05.048
collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI). Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Atherosclerosis. 2018 Aug;275:141-148. https://doi.org/10.1016/j.atherosclerosis.2018.05.048
collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI). / Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population : An individual participant data meta-analysis. In: Atherosclerosis. 2018 ; Vol. 275. pp. 141-148.
@article{5b10fcb8d5a54ec8993423ff642a11b0,
title = "Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis",
abstract = "Background and aims: The ankle–brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. Methods: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality. Results: During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95{\%} confidence interval [CI] 0.91–1.27) for ABI of 1.00–1.09, HR 1.37 (95{\%} CI 1.04–1.81) for ABI of 0.91–0.99, and HR 1.60 (95{\%} CI 1.06–2.41) for ABI of ≤0.90, compared with ABI of 1.10–1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95{\%} CI 1.14–5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome. Conclusions: The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.",
author = "{collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI)} and Toshiaki Ohkuma and Toshiharu Ninomiya and Hirofumi Tomiyama and Kazuomi Kario and Satoshi Hoshide and Yoshikuni Kita and Toyoshi Inoguchi and Yasutaka Maeda and Katsuhiko Kohara and Yasuharu Tabara and Motoyuki Nakamura and Takayoshi Ohkubo and Hirotaka Watada and Masanori Munakata and Mitsuru Ohishi and Norihisa Ito and Michinari Nakamura and Tetsuo Shoji and Charalambos Vlachopoulos and Victor Aboyans and Akira Yamashina",
year = "2018",
month = "8",
doi = "10.1016/j.atherosclerosis.2018.05.048",
language = "English",
volume = "275",
pages = "141--148",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population

T2 - An individual participant data meta-analysis

AU - collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-BAVEL-ABI)

AU - Ohkuma, Toshiaki

AU - Ninomiya, Toshiharu

AU - Tomiyama, Hirofumi

AU - Kario, Kazuomi

AU - Hoshide, Satoshi

AU - Kita, Yoshikuni

AU - Inoguchi, Toyoshi

AU - Maeda, Yasutaka

AU - Kohara, Katsuhiko

AU - Tabara, Yasuharu

AU - Nakamura, Motoyuki

AU - Ohkubo, Takayoshi

AU - Watada, Hirotaka

AU - Munakata, Masanori

AU - Ohishi, Mitsuru

AU - Ito, Norihisa

AU - Nakamura, Michinari

AU - Shoji, Tetsuo

AU - Vlachopoulos, Charalambos

AU - Aboyans, Victor

AU - Yamashina, Akira

PY - 2018/8

Y1 - 2018/8

N2 - Background and aims: The ankle–brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. Methods: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality. Results: During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95% confidence interval [CI] 0.91–1.27) for ABI of 1.00–1.09, HR 1.37 (95% CI 1.04–1.81) for ABI of 0.91–0.99, and HR 1.60 (95% CI 1.06–2.41) for ABI of ≤0.90, compared with ABI of 1.10–1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95% CI 1.14–5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome. Conclusions: The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.

AB - Background and aims: The ankle–brachial index (ABI) is a predictor of cardiovascular disease (CVD) and premature death. However, few studies on this marker are available in the general Asian populations. This study aimed to investigate the association between ABI measured with oscillometry and the risk of these outcomes. Methods: We conducted an individual participant data meta-analysis in 10,679 community-dwelling Japanese individuals without a history of CVD. The primary outcome was a composite of CVD events and all-cause mortality. Results: During an average of 7.8 years of follow-up, 720 participants experienced the primary outcome. The multivariable-adjusted hazard ratios (HRs) of the primary outcome significantly increased with a lower ABI. The HRs were 1.07 (95% confidence interval [CI] 0.91–1.27) for ABI of 1.00–1.09, HR 1.37 (95% CI 1.04–1.81) for ABI of 0.91–0.99, and HR 1.60 (95% CI 1.06–2.41) for ABI of ≤0.90, compared with ABI of 1.10–1.19. Furthermore, a high ABI (≥1.30) was associated with a greater risk of outcome (HR 2.42 [95% CI 1.14–5.13]). Similar tendencies were observed for CVD events alone and all-cause mortality alone. Addition of ABI to a model with the Framingham risk score marginally improved the c-statistics (p = 0.08) and integrated discrimination improvement (p < 0.05) for the primary outcome. Conclusions: The present study suggests that lower and higher ABI are significantly associated with an increased risk of CVD and all-cause mortality in the Japanese population. The ABI, which is easily measured by oscillometry, may be incorporated into daily clinical practice to identify high-risk populations.

UR - http://www.scopus.com/inward/record.url?scp=85048256027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048256027&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2018.05.048

DO - 10.1016/j.atherosclerosis.2018.05.048

M3 - Article

AN - SCOPUS:85048256027

VL - 275

SP - 141

EP - 148

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -