Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria

Kei Nagai, Kunihiro Yamagata, Reiko Ohkubo, Chie Saito, Koichi Asahi, Kunitoshi Iseki, Kenjiro Kimura, Toshiki Moriyama, Ichiei Narita, Shouichi Fujimoto, Kazuhiko Tsuruya, Tsuneo Konta, Masahide Kondo, Tsuyoshi Watanabe

Research output: Contribution to journalArticle

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Abstract

Aims Chronic kidney disease is a risk factor of the development of cardiovascular disease (CVD). However, it is not clear whether decline of glomerular filtration rate (GFR), not reduced GFR, is a risk factor for the incidence of CVD independent of proteinuria. Methods By using a population-based 521 123 person-years longitudinal cohort receiving annual health checkups from 2008 to 2010, we examined whether the annual decline of estimated GFR is a risk factor for CVD development independent of proteinuria. Results During the follow-up period, there were 12 041 newly developed CVD events, comprising 4426 stroke events and/or 8298 cardiac events. As expected, both reduced estimated GFR and proteinuria were risk factors for the development of CVD in our study population. Moreover, annual decline of estimated GFR was a significant and independent risk factor for the incidence of CVD (HR [95% CI], 1.23 [1.18-1.28] in males or 1.14 [1.10-1.18] in females for -10% per year) with covariant adjustment for proteinuria and reduced estimated GFR. Conclusion Annual decline of GFR is an independent risk factor for CVD. Serial measurement of both creatinine and proteinuria would be better to predict the incidence of CVD in the general population. Summary at a Glance Previous studies have shown that annual decline or increment estimated glomerular filtration rate may influence prognosis. This study focuses on the cardiovascular events and demonstrates that the annual decline rate in eGFR is a risk factor for cardiovascular events independent of proteinuria by using a large longitudinal Japanese population-based study of participants receiving annual health checkups from 2008-2010. To reduce the incidence of cardiovascular events in the general population, serial measurement of serum creatinine to obtain the change rate in eGFR is warranted.

Original languageEnglish
Pages (from-to)574-580
Number of pages7
JournalNephrology
Volume19
Issue number9
DOIs
Publication statusPublished - Jan 1 2014

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Glomerular Filtration Rate
Proteinuria
Cardiovascular Diseases
Population
Incidence
Creatinine
Health
Chronic Renal Insufficiency
Stroke
Serum

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Nagai, K., Yamagata, K., Ohkubo, R., Saito, C., Asahi, K., Iseki, K., ... Watanabe, T. (2014). Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria. Nephrology, 19(9), 574-580. https://doi.org/10.1111/nep.12286

Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria. / Nagai, Kei; Yamagata, Kunihiro; Ohkubo, Reiko; Saito, Chie; Asahi, Koichi; Iseki, Kunitoshi; Kimura, Kenjiro; Moriyama, Toshiki; Narita, Ichiei; Fujimoto, Shouichi; Tsuruya, Kazuhiko; Konta, Tsuneo; Kondo, Masahide; Watanabe, Tsuyoshi.

In: Nephrology, Vol. 19, No. 9, 01.01.2014, p. 574-580.

Research output: Contribution to journalArticle

Nagai, K, Yamagata, K, Ohkubo, R, Saito, C, Asahi, K, Iseki, K, Kimura, K, Moriyama, T, Narita, I, Fujimoto, S, Tsuruya, K, Konta, T, Kondo, M & Watanabe, T 2014, 'Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria', Nephrology, vol. 19, no. 9, pp. 574-580. https://doi.org/10.1111/nep.12286
Nagai, Kei ; Yamagata, Kunihiro ; Ohkubo, Reiko ; Saito, Chie ; Asahi, Koichi ; Iseki, Kunitoshi ; Kimura, Kenjiro ; Moriyama, Toshiki ; Narita, Ichiei ; Fujimoto, Shouichi ; Tsuruya, Kazuhiko ; Konta, Tsuneo ; Kondo, Masahide ; Watanabe, Tsuyoshi. / Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria. In: Nephrology. 2014 ; Vol. 19, No. 9. pp. 574-580.
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abstract = "Aims Chronic kidney disease is a risk factor of the development of cardiovascular disease (CVD). However, it is not clear whether decline of glomerular filtration rate (GFR), not reduced GFR, is a risk factor for the incidence of CVD independent of proteinuria. Methods By using a population-based 521 123 person-years longitudinal cohort receiving annual health checkups from 2008 to 2010, we examined whether the annual decline of estimated GFR is a risk factor for CVD development independent of proteinuria. Results During the follow-up period, there were 12 041 newly developed CVD events, comprising 4426 stroke events and/or 8298 cardiac events. As expected, both reduced estimated GFR and proteinuria were risk factors for the development of CVD in our study population. Moreover, annual decline of estimated GFR was a significant and independent risk factor for the incidence of CVD (HR [95{\%} CI], 1.23 [1.18-1.28] in males or 1.14 [1.10-1.18] in females for -10{\%} per year) with covariant adjustment for proteinuria and reduced estimated GFR. Conclusion Annual decline of GFR is an independent risk factor for CVD. Serial measurement of both creatinine and proteinuria would be better to predict the incidence of CVD in the general population. Summary at a Glance Previous studies have shown that annual decline or increment estimated glomerular filtration rate may influence prognosis. This study focuses on the cardiovascular events and demonstrates that the annual decline rate in eGFR is a risk factor for cardiovascular events independent of proteinuria by using a large longitudinal Japanese population-based study of participants receiving annual health checkups from 2008-2010. To reduce the incidence of cardiovascular events in the general population, serial measurement of serum creatinine to obtain the change rate in eGFR is warranted.",
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AU - Nagai, Kei

AU - Yamagata, Kunihiro

AU - Ohkubo, Reiko

AU - Saito, Chie

AU - Asahi, Koichi

AU - Iseki, Kunitoshi

AU - Kimura, Kenjiro

AU - Moriyama, Toshiki

AU - Narita, Ichiei

AU - Fujimoto, Shouichi

AU - Tsuruya, Kazuhiko

AU - Konta, Tsuneo

AU - Kondo, Masahide

AU - Watanabe, Tsuyoshi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Aims Chronic kidney disease is a risk factor of the development of cardiovascular disease (CVD). However, it is not clear whether decline of glomerular filtration rate (GFR), not reduced GFR, is a risk factor for the incidence of CVD independent of proteinuria. Methods By using a population-based 521 123 person-years longitudinal cohort receiving annual health checkups from 2008 to 2010, we examined whether the annual decline of estimated GFR is a risk factor for CVD development independent of proteinuria. Results During the follow-up period, there were 12 041 newly developed CVD events, comprising 4426 stroke events and/or 8298 cardiac events. As expected, both reduced estimated GFR and proteinuria were risk factors for the development of CVD in our study population. Moreover, annual decline of estimated GFR was a significant and independent risk factor for the incidence of CVD (HR [95% CI], 1.23 [1.18-1.28] in males or 1.14 [1.10-1.18] in females for -10% per year) with covariant adjustment for proteinuria and reduced estimated GFR. Conclusion Annual decline of GFR is an independent risk factor for CVD. Serial measurement of both creatinine and proteinuria would be better to predict the incidence of CVD in the general population. Summary at a Glance Previous studies have shown that annual decline or increment estimated glomerular filtration rate may influence prognosis. This study focuses on the cardiovascular events and demonstrates that the annual decline rate in eGFR is a risk factor for cardiovascular events independent of proteinuria by using a large longitudinal Japanese population-based study of participants receiving annual health checkups from 2008-2010. To reduce the incidence of cardiovascular events in the general population, serial measurement of serum creatinine to obtain the change rate in eGFR is warranted.

AB - Aims Chronic kidney disease is a risk factor of the development of cardiovascular disease (CVD). However, it is not clear whether decline of glomerular filtration rate (GFR), not reduced GFR, is a risk factor for the incidence of CVD independent of proteinuria. Methods By using a population-based 521 123 person-years longitudinal cohort receiving annual health checkups from 2008 to 2010, we examined whether the annual decline of estimated GFR is a risk factor for CVD development independent of proteinuria. Results During the follow-up period, there were 12 041 newly developed CVD events, comprising 4426 stroke events and/or 8298 cardiac events. As expected, both reduced estimated GFR and proteinuria were risk factors for the development of CVD in our study population. Moreover, annual decline of estimated GFR was a significant and independent risk factor for the incidence of CVD (HR [95% CI], 1.23 [1.18-1.28] in males or 1.14 [1.10-1.18] in females for -10% per year) with covariant adjustment for proteinuria and reduced estimated GFR. Conclusion Annual decline of GFR is an independent risk factor for CVD. Serial measurement of both creatinine and proteinuria would be better to predict the incidence of CVD in the general population. Summary at a Glance Previous studies have shown that annual decline or increment estimated glomerular filtration rate may influence prognosis. This study focuses on the cardiovascular events and demonstrates that the annual decline rate in eGFR is a risk factor for cardiovascular events independent of proteinuria by using a large longitudinal Japanese population-based study of participants receiving annual health checkups from 2008-2010. To reduce the incidence of cardiovascular events in the general population, serial measurement of serum creatinine to obtain the change rate in eGFR is warranted.

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