Anserine/carnosine supplementation suppresses the expression of the inflammatory chemokine CCL24 in peripheral blood mononuclear cells from elderly people

Yoshinori Katakura, Mamoru Totsuka, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study. The ACS group was administered 1.0 g of anserine/carnosine (3:1) for 3 months. A microarray analysis and subsequent quantitative real-time polymerase chain reaction (qRT-PCR) analysis of peripheral blood mononuclear cells (PBMCs) showed decreased expression of CCL24, an inflammatory chemokine (p < 0.05). Verbal memory, assessed using the Wechsler memory scale–logical memory, was preserved in the ACS group. An age-restricted sub-analysis showed significant verbal memory preservaation by ACS in participants who were in their 60s (active, n = 12; placebo, n = 9; p = 0.048) and 70s (active, n = 7; placebo, n = 11; p = 0.017). The suppression of CCL24 expression was greatest in people who were in their 70s (p < 0.01). There was a significant correlation between the preservation of verbal memory and suppression of CCL24 expression in the group that was in the 70s (Poisson correlation, r = 0.46, p < 0.05). These results suggest that ACS may preserve verbal episodic memory, probably owing to CCL24 suppression in the blood, especially in elderly participants.

Original languageEnglish
Article number1199
JournalNutrients
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Chemokine CCL24
Anserine
anserine
Carnosine
carnosine
mononuclear leukocytes
Blood Cells
placebos
Placebos
chemokines
volunteers
Episodic Memory
Microarray Analysis
chemokine CCL24
Chemokines
preserves
Real-Time Polymerase Chain Reaction
Volunteers
Healthy Volunteers
quantitative polymerase chain reaction

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

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Anserine/carnosine supplementation suppresses the expression of the inflammatory chemokine CCL24 in peripheral blood mononuclear cells from elderly people. / Katakura, Yoshinori; Totsuka, Mamoru; Imabayashi, Etsuko; Matsuda, Hiroshi; Hisatsune, Tatsuhiro.

In: Nutrients, Vol. 9, No. 11, 1199, 01.11.2017.

Research output: Contribution to journalArticle

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