Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain

Toshihide Kuroki, Y. Tatebayashi, K. Ide, Y. Yonezawa, T. Tsutsumi, T. Matsumoto, M. Hirano, H. Uchimura

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the present study, we investigated the effects of ceruletide (CL), a cholecystokinin analog, on the neurochemical response to non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine (PCP) and MK-801, of the dopaminergic neuron systems in the discrete regions of the rat brain. Systemically administered PCP (7.5 mg/kg, i.p.) or MK-801 (1.0 mg/kg, i.p.) produced significant increases in the tissue contents of dopamine metabolite, homovanillic acid (HVA), in the prefrontal cortex, the nucleus accumbens and the olfactory tubercle but not in the nucleus caudatus putamen after 60 min. The effects of NMDA receptor antagonists in the nucleus accumbens and the prefrontal cortex were partially antagonized by pretreatment with CL (80 and 400 μg/kg, i.p., at 60 min prior to the drugs). While CL alone decreased the dopaminergic metabolism only in the nigrostriatal pathways in naive rats, the present results indicated that CL also attenuates the activities of the meso-limbic and meso-cortical dopaminergic neuron systems when these are enhanced by either PCP or MK-801.

Original languageEnglish
Pages (from-to)167-173
Number of pages7
JournalNeuropeptides
Volume21
Issue number3
DOIs
Publication statusPublished - Jan 1 1992

Fingerprint

Ceruletide
Phencyclidine
Dizocilpine Maleate
Dopaminergic Neurons
Cholecystokinin
N-Methyl-D-Aspartate Receptors
Nucleus Accumbens
Brain
Prefrontal Cortex
Homovanillic Acid
Caudate Nucleus
Putamen
Dopamine
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

Cite this

Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain. / Kuroki, Toshihide; Tatebayashi, Y.; Ide, K.; Yonezawa, Y.; Tsutsumi, T.; Matsumoto, T.; Hirano, M.; Uchimura, H.

In: Neuropeptides, Vol. 21, No. 3, 01.01.1992, p. 167-173.

Research output: Contribution to journalArticle

@article{6f6a6423116f4aa4b732bde059a4f7cf,
title = "Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain",
abstract = "In the present study, we investigated the effects of ceruletide (CL), a cholecystokinin analog, on the neurochemical response to non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine (PCP) and MK-801, of the dopaminergic neuron systems in the discrete regions of the rat brain. Systemically administered PCP (7.5 mg/kg, i.p.) or MK-801 (1.0 mg/kg, i.p.) produced significant increases in the tissue contents of dopamine metabolite, homovanillic acid (HVA), in the prefrontal cortex, the nucleus accumbens and the olfactory tubercle but not in the nucleus caudatus putamen after 60 min. The effects of NMDA receptor antagonists in the nucleus accumbens and the prefrontal cortex were partially antagonized by pretreatment with CL (80 and 400 μg/kg, i.p., at 60 min prior to the drugs). While CL alone decreased the dopaminergic metabolism only in the nigrostriatal pathways in naive rats, the present results indicated that CL also attenuates the activities of the meso-limbic and meso-cortical dopaminergic neuron systems when these are enhanced by either PCP or MK-801.",
author = "Toshihide Kuroki and Y. Tatebayashi and K. Ide and Y. Yonezawa and T. Tsutsumi and T. Matsumoto and M. Hirano and H. Uchimura",
year = "1992",
month = "1",
day = "1",
doi = "10.1016/0143-4179(92)90041-T",
language = "English",
volume = "21",
pages = "167--173",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "3",

}

TY - JOUR

T1 - Antagonism of ceruletide, a cholecystokinin analog, to the neurochemical effects of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and MK-801, on regional dopaminergic neurons in the rat brain

AU - Kuroki, Toshihide

AU - Tatebayashi, Y.

AU - Ide, K.

AU - Yonezawa, Y.

AU - Tsutsumi, T.

AU - Matsumoto, T.

AU - Hirano, M.

AU - Uchimura, H.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - In the present study, we investigated the effects of ceruletide (CL), a cholecystokinin analog, on the neurochemical response to non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine (PCP) and MK-801, of the dopaminergic neuron systems in the discrete regions of the rat brain. Systemically administered PCP (7.5 mg/kg, i.p.) or MK-801 (1.0 mg/kg, i.p.) produced significant increases in the tissue contents of dopamine metabolite, homovanillic acid (HVA), in the prefrontal cortex, the nucleus accumbens and the olfactory tubercle but not in the nucleus caudatus putamen after 60 min. The effects of NMDA receptor antagonists in the nucleus accumbens and the prefrontal cortex were partially antagonized by pretreatment with CL (80 and 400 μg/kg, i.p., at 60 min prior to the drugs). While CL alone decreased the dopaminergic metabolism only in the nigrostriatal pathways in naive rats, the present results indicated that CL also attenuates the activities of the meso-limbic and meso-cortical dopaminergic neuron systems when these are enhanced by either PCP or MK-801.

AB - In the present study, we investigated the effects of ceruletide (CL), a cholecystokinin analog, on the neurochemical response to non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine (PCP) and MK-801, of the dopaminergic neuron systems in the discrete regions of the rat brain. Systemically administered PCP (7.5 mg/kg, i.p.) or MK-801 (1.0 mg/kg, i.p.) produced significant increases in the tissue contents of dopamine metabolite, homovanillic acid (HVA), in the prefrontal cortex, the nucleus accumbens and the olfactory tubercle but not in the nucleus caudatus putamen after 60 min. The effects of NMDA receptor antagonists in the nucleus accumbens and the prefrontal cortex were partially antagonized by pretreatment with CL (80 and 400 μg/kg, i.p., at 60 min prior to the drugs). While CL alone decreased the dopaminergic metabolism only in the nigrostriatal pathways in naive rats, the present results indicated that CL also attenuates the activities of the meso-limbic and meso-cortical dopaminergic neuron systems when these are enhanced by either PCP or MK-801.

UR - http://www.scopus.com/inward/record.url?scp=0026554094&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026554094&partnerID=8YFLogxK

U2 - 10.1016/0143-4179(92)90041-T

DO - 10.1016/0143-4179(92)90041-T

M3 - Article

VL - 21

SP - 167

EP - 173

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 3

ER -