Anterior hypothalamic lesions inhibit antigen-induced airway eosinophilia in rats

Masahiro Irie, Shoji Nagata, Yutaka Endo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Although previous studies have found that electrolytic lesions of the anterior hypothalamic area (AHA) resulted in the suppression of anaphylaxis, their effect on late allergic responses has scarcely been investigated. To clarify the role of the AHA on possible late asthmatic responses, including their neuroendocrinological mechanisms, we examined the effect of electrolytic AHA lesions on antigen-induced eosinophilic infiltration into the airway tract and measured the plasma corticosterone and catecholamine levels in sensitized rats, i.e. a model of bronchial asthma. Methods: The rats were randomly divided into 3 groups, including: (1) an unoperated control group; (2) a sham AHA-lesioned group and (3) an AHA-lesioned group. Then, we investigated antigen-induced eosinophilic infiltration into right bronchoalveolar lavage fluid (BALF) and the lamina propria mucosae of the left main bronchus. Results: The AHA-lesioned group showed the significantly lowest number of eosinophils in both the BALF (p < 0.01) and the main bronchus (p < 0.05). The plasma adrenaline levels in the AHA-lesioned group were significantly higher than those in the other groups (p < 0.05). No differences were found in the plasma corticosterone or noradrenaline levels among the 3 groups. Conclusion: This study provides evidence that AHA lesions inhibit not only anaphylaxis, but also late asthmatic response related to airway eosinophilic infiltration, possibly via an alteration of the sympathetic nervous function.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalNeuroImmunoModulation
Volume10
Issue number5
DOIs
Publication statusPublished - Dec 1 2002
Externally publishedYes

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Anterior Hypothalamic Nucleus
Eosinophilia
Antigens
Bronchoalveolar Lavage Fluid
Anaphylaxis
Bronchi
Corticosterone
Mucous Membrane
Eosinophils
Epinephrine
Catecholamines
Norepinephrine
Asthma
Control Groups

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

Cite this

Anterior hypothalamic lesions inhibit antigen-induced airway eosinophilia in rats. / Irie, Masahiro; Nagata, Shoji; Endo, Yutaka.

In: NeuroImmunoModulation, Vol. 10, No. 5, 01.12.2002, p. 305-309.

Research output: Contribution to journalArticle

Irie, Masahiro ; Nagata, Shoji ; Endo, Yutaka. / Anterior hypothalamic lesions inhibit antigen-induced airway eosinophilia in rats. In: NeuroImmunoModulation. 2002 ; Vol. 10, No. 5. pp. 305-309.
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