Anterior mediastinal solid tumours in adults: Characterisation using dynamic contrast-enhanced MRI, diffusion-weighted MRI, and FDG-PET/CT

H. Yabuuchi, Y. Matsuo, K. Abe, S. Baba, S. Sunami, T. Kamitani, M. Yonezawa, Y. Yamasaki, S. Kawanami, M. Nagao, T. Okamoto, K. Nakamura, H. Yamamoto, M. Sasaki, H. Honda

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Abstract

Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods Forty-eight histologically confirmed anterior mediastinal solid tumours in 48 patients (24 men, 24 women; age range 21-83 years, mean 50.7 years) were examined. The parameters analysed were maximal diameter, presence of capsule/septa on T2-weighted images, time-signal intensity curves (TICs), apparent diffusion coefficient (ADC), and maximum standardised uptake value (SUVmax). Also examined was whether any differences between histological types could be seen in these parameters. In a validation study, 42 anterior mediastinal solid tumours in 42 patients were examined consecutively. Results The washout pattern on TIC was seen only in thymic epithelial tumours (20/32). SUVmax of lymphoma (mean, 17.9), malignant germ cell tumours (14.2), and thymic carcinomas (15.6) were significantly higher than that of thymomas (6.1). The mean maximal diameter of thymic epithelial tumours was significantly smaller than that of lymphomas (p<0.01) and malignant germ cell tumours (p<0.05). The validation study also yielded high accuracy (38/42, 91%) in differentiation among the anterior mediastinal solid tumours. Conclusion The SUVmax, TIC pattern on DCE-MRI, and maximal diameter might be useful to differentiate anterior mediastinal solid tumours in adults.

Original languageEnglish
Pages (from-to)1289-1298
Number of pages10
JournalClinical Radiology
Volume70
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

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Diffusion Magnetic Resonance Imaging
Glucose
Thymoma
Validation Studies
Germ Cell and Embryonal Neoplasms
Neoplasms
Lymphoma
Magnetic Resonance Imaging
Capsules
Positron Emission Tomography Computed Tomography

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Anterior mediastinal solid tumours in adults : Characterisation using dynamic contrast-enhanced MRI, diffusion-weighted MRI, and FDG-PET/CT. / Yabuuchi, H.; Matsuo, Y.; Abe, K.; Baba, S.; Sunami, S.; Kamitani, T.; Yonezawa, M.; Yamasaki, Y.; Kawanami, S.; Nagao, M.; Okamoto, T.; Nakamura, K.; Yamamoto, H.; Sasaki, M.; Honda, H.

In: Clinical Radiology, Vol. 70, No. 11, 01.11.2015, p. 1289-1298.

Research output: Contribution to journalArticle

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title = "Anterior mediastinal solid tumours in adults: Characterisation using dynamic contrast-enhanced MRI, diffusion-weighted MRI, and FDG-PET/CT",
abstract = "Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods Forty-eight histologically confirmed anterior mediastinal solid tumours in 48 patients (24 men, 24 women; age range 21-83 years, mean 50.7 years) were examined. The parameters analysed were maximal diameter, presence of capsule/septa on T2-weighted images, time-signal intensity curves (TICs), apparent diffusion coefficient (ADC), and maximum standardised uptake value (SUVmax). Also examined was whether any differences between histological types could be seen in these parameters. In a validation study, 42 anterior mediastinal solid tumours in 42 patients were examined consecutively. Results The washout pattern on TIC was seen only in thymic epithelial tumours (20/32). SUVmax of lymphoma (mean, 17.9), malignant germ cell tumours (14.2), and thymic carcinomas (15.6) were significantly higher than that of thymomas (6.1). The mean maximal diameter of thymic epithelial tumours was significantly smaller than that of lymphomas (p<0.01) and malignant germ cell tumours (p<0.05). The validation study also yielded high accuracy (38/42, 91{\%}) in differentiation among the anterior mediastinal solid tumours. Conclusion The SUVmax, TIC pattern on DCE-MRI, and maximal diameter might be useful to differentiate anterior mediastinal solid tumours in adults.",
author = "H. Yabuuchi and Y. Matsuo and K. Abe and S. Baba and S. Sunami and T. Kamitani and M. Yonezawa and Y. Yamasaki and S. Kawanami and M. Nagao and T. Okamoto and K. Nakamura and H. Yamamoto and M. Sasaki and H. Honda",
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T1 - Anterior mediastinal solid tumours in adults

T2 - Characterisation using dynamic contrast-enhanced MRI, diffusion-weighted MRI, and FDG-PET/CT

AU - Yabuuchi, H.

AU - Matsuo, Y.

AU - Abe, K.

AU - Baba, S.

AU - Sunami, S.

AU - Kamitani, T.

AU - Yonezawa, M.

AU - Yamasaki, Y.

AU - Kawanami, S.

AU - Nagao, M.

AU - Okamoto, T.

AU - Nakamura, K.

AU - Yamamoto, H.

AU - Sasaki, M.

AU - Honda, H.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods Forty-eight histologically confirmed anterior mediastinal solid tumours in 48 patients (24 men, 24 women; age range 21-83 years, mean 50.7 years) were examined. The parameters analysed were maximal diameter, presence of capsule/septa on T2-weighted images, time-signal intensity curves (TICs), apparent diffusion coefficient (ADC), and maximum standardised uptake value (SUVmax). Also examined was whether any differences between histological types could be seen in these parameters. In a validation study, 42 anterior mediastinal solid tumours in 42 patients were examined consecutively. Results The washout pattern on TIC was seen only in thymic epithelial tumours (20/32). SUVmax of lymphoma (mean, 17.9), malignant germ cell tumours (14.2), and thymic carcinomas (15.6) were significantly higher than that of thymomas (6.1). The mean maximal diameter of thymic epithelial tumours was significantly smaller than that of lymphomas (p<0.01) and malignant germ cell tumours (p<0.05). The validation study also yielded high accuracy (38/42, 91%) in differentiation among the anterior mediastinal solid tumours. Conclusion The SUVmax, TIC pattern on DCE-MRI, and maximal diameter might be useful to differentiate anterior mediastinal solid tumours in adults.

AB - Aim To find significant parameters to characterise anterior mediastinal solid tumours in adults using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), diffusion-weighted MRI (DWI), and combined 2-[18F]-fluoro-2-deoxy-d-glucose positron-emission tomography/computed tomography (FDG-PET/CT). Materials and methods Forty-eight histologically confirmed anterior mediastinal solid tumours in 48 patients (24 men, 24 women; age range 21-83 years, mean 50.7 years) were examined. The parameters analysed were maximal diameter, presence of capsule/septa on T2-weighted images, time-signal intensity curves (TICs), apparent diffusion coefficient (ADC), and maximum standardised uptake value (SUVmax). Also examined was whether any differences between histological types could be seen in these parameters. In a validation study, 42 anterior mediastinal solid tumours in 42 patients were examined consecutively. Results The washout pattern on TIC was seen only in thymic epithelial tumours (20/32). SUVmax of lymphoma (mean, 17.9), malignant germ cell tumours (14.2), and thymic carcinomas (15.6) were significantly higher than that of thymomas (6.1). The mean maximal diameter of thymic epithelial tumours was significantly smaller than that of lymphomas (p<0.01) and malignant germ cell tumours (p<0.05). The validation study also yielded high accuracy (38/42, 91%) in differentiation among the anterior mediastinal solid tumours. Conclusion The SUVmax, TIC pattern on DCE-MRI, and maximal diameter might be useful to differentiate anterior mediastinal solid tumours in adults.

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DO - 10.1016/j.crad.2015.07.004

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