Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder

Mitsuru Kikuchi, Yuko Yoshimura, Kiyomi Shitamichi, Sanae Ueno, Hirotoshi Hiraishi, Toshio Munesue, Tetsu Hirosawa, Yasuki Ono, Tsunehisa Tsubokawa, Yoshihiro Inoue, Manabu Oi, Yo Niida, Gerard B. Remijn, Tsutomu Takahashi, Michio Suzuki, Haruhiro Higashida, Yoshio Minabe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Socio-communicative impairments are salient features of autism spectrum disorder (ASD) from a young age. The anterior prefrontal cortex (aPFC), or Brodmann area 10, is a key processing area for social function, and atypical development of this area is thought to play a role in the social deficits in ASD. It is important to understand these brain functions in developing children with ASD. However, these brain functions have not yet been well described under conscious conditions in young children with ASD. In the present study, we focused on the brain hemodynamic functional connectivity between the right and the left aPFC in children with ASD and typically developing (TD) children and investigated whether there was a correlation between this connectivity and social ability. Brain hemodynamic fluctuations were measured non-invasively by near-infrared spectroscopy (NIRS) in 3- to 7-year-old children with ASD (n = 15) and gender- and age-matched TD children (n = 15). The functional connectivity between the right and the left aPFC was assessed by measuring the coherence for low-frequency spontaneous fluctuations (0.01 - 0.10 Hz) during a narrated picture-card show. Coherence analysis demonstrated that children with ASD had a significantly higher inter-hemispheric connectivity with 0.02-Hz fluctuations, whereas a power analysis did not demonstrate significant differences between the two groups in terms of low frequency fluctuations (0.01 - 0.10 Hz). This aberrant higher connectivity in children with ASD was positively correlated with the severity of social deficit, as scored with the Autism Diagnostic Observation Schedule. This is the first study to demonstrate aberrant brain functional connectivity between the right and the left aPFC under conscious conditions in young children with ASD.

Original languageEnglish
Article numbere56087
JournalPloS one
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 13 2013

Fingerprint

Hemodynamics
hemodynamics
Brain
Prefrontal Cortex
brain
Near infrared spectroscopy
Autism Spectrum Disorder
autism
Near-Infrared Spectroscopy
Autistic Disorder
near-infrared spectroscopy
Processing
Appointments and Schedules
Observation
prefrontal cortex
gender

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder. / Kikuchi, Mitsuru; Yoshimura, Yuko; Shitamichi, Kiyomi; Ueno, Sanae; Hiraishi, Hirotoshi; Munesue, Toshio; Hirosawa, Tetsu; Ono, Yasuki; Tsubokawa, Tsunehisa; Inoue, Yoshihiro; Oi, Manabu; Niida, Yo; Remijn, Gerard B.; Takahashi, Tsutomu; Suzuki, Michio; Higashida, Haruhiro; Minabe, Yoshio.

In: PloS one, Vol. 8, No. 2, e56087, 13.02.2013.

Research output: Contribution to journalArticle

Kikuchi, M, Yoshimura, Y, Shitamichi, K, Ueno, S, Hiraishi, H, Munesue, T, Hirosawa, T, Ono, Y, Tsubokawa, T, Inoue, Y, Oi, M, Niida, Y, Remijn, GB, Takahashi, T, Suzuki, M, Higashida, H & Minabe, Y 2013, 'Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder', PloS one, vol. 8, no. 2, e56087. https://doi.org/10.1371/journal.pone.0056087
Kikuchi, Mitsuru ; Yoshimura, Yuko ; Shitamichi, Kiyomi ; Ueno, Sanae ; Hiraishi, Hirotoshi ; Munesue, Toshio ; Hirosawa, Tetsu ; Ono, Yasuki ; Tsubokawa, Tsunehisa ; Inoue, Yoshihiro ; Oi, Manabu ; Niida, Yo ; Remijn, Gerard B. ; Takahashi, Tsutomu ; Suzuki, Michio ; Higashida, Haruhiro ; Minabe, Yoshio. / Anterior Prefrontal Hemodynamic Connectivity in Conscious 3- to 7-Year-Old Children with Typical Development and Autism Spectrum Disorder. In: PloS one. 2013 ; Vol. 8, No. 2.
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