Anti-allergic action of O-methylated EGCG in green tea cultivar Benifuuki

Mari Maeda-Yamamoto, Hirofumi Tachibana

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The anti-allergic effect of epigallocatechin-3-O-(3-O-methyl) gallate (EGCG3″Me) and epigallocatechin-3-O-(4-O-methyl) gallate (EGCG4″Me) isolated from Japanese or Taiwanese tea (Camellia sinensis L.) leaves. These catechins strongly inhibited mast cell activation and histamine release after FcepsilonRI cross-linking through the suppression of tyrosine phosphorylation (Lyn) of cellular protein kinase, and the suppression of myosin light chain phosphorylation and high-affinity IgE receptor expression via the binding to 67kDa laminin receptor. A double blind clinical study on subjects with Japanese cedar pollinosis was carried out. At the eleventh weeks after starting to intake, the most severe cedar pollen scattering period, symptoms i.e. blowing nose, itch of eyes were significantly relieved in Benifuuki group compared with placebo group. Over one consecutive month intake of Benifuuki green containing O-methylated catechin tea was useful for reduction of some symptoms derived from Japanese cedar pollinosis, and did not affect any normal immune response in the subjects with Japanese cedar-pollinosis. From the investigation that the effects of cultivars, tea seasons of crops and manufacturing methods, green or semi-fermented teas, made from fully-matured Benifuuki in second crop season, should be consumed. It is possible to develop functional articles such as beverage or food with this Benifuuki green tea.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalJournal of Food and Drug Analysis
Volume20
Issue numberSUPPL.1
Publication statusPublished - Apr 2012

Fingerprint

tea (beverage)
Anti-Allergic Agents
green tea
Tea
hay fever
Cryptomeria japonica
Cryptomeria
Seasonal Allergic Rhinitis
epigallocatechin
cultivars
Catechin
signs and symptoms (animals and humans)
phosphorylation
myosin light chains
receptors
laminin
Camellia sinensis
Phosphorylation
Laminin Receptors
mast cells

All Science Journal Classification (ASJC) codes

  • Food Science
  • Pharmacology

Cite this

Anti-allergic action of O-methylated EGCG in green tea cultivar Benifuuki. / Maeda-Yamamoto, Mari; Tachibana, Hirofumi.

In: Journal of Food and Drug Analysis, Vol. 20, No. SUPPL.1, 04.2012, p. 313-317.

Research output: Contribution to journalArticle

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