Anti-allergic effect of strawberry extract

Akira Iwamoto, Aiko Inoue, Yuichi Inoue, Koji Yamada, Hirofumi Tachibana, Hiroharu Kawahara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We examined the anti-allergic effect of strawberry extract on human peripheral blood mononuclear cells (PBMCs) and atopic dermatitis model mice NC/NgaTndCrlj. The addition of strawberry extract suppressed total IgE production in the cedar pollen antigen Cry j 1-stimulated PBMCs. Flow cytometric analysis showed that strawberry extract decreased the rate of CD3+CD4+ helper T cells by 17.3% and increased the rate of CD3+CD8+ cytotoxic T cells by 19.7% in PBMCs. Moreover, the extract inhibited the expression level of GATA3 that is the master regulator of type 2 helper T cells (Th2) in human primary pan T cells isolated from PBMCs. Oral administration of strawberry extract lowered dermatitis scores and serum IgE levels in mice. In addition, it also decreased the GATA3 expression level in mouse blood cells. These results revealed that strawberry extract suppressed the severity of atopic dermatitis through the down-regulation of serum IgE by inhibition of Th2 differentiation.

Original languageEnglish
Pages (from-to)1947-1955
Number of pages9
JournalJournal of Functional Foods
Volume5
Issue number4
DOIs
Publication statusPublished - Oct 1 2013

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Fragaria
Anti-Allergic Agents
strawberries
Blood Cells
mononuclear leukocytes
Immunoglobulin E
extracts
T-lymphocytes
Atopic Dermatitis
atopic dermatitis
T-Lymphocytes
Th2 Cells
Dermatitis
Helper-Inducer T-Lymphocytes
Pollen
Serum
mice
Oral Administration
dermatitis
blood cells

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Iwamoto, A., Inoue, A., Inoue, Y., Yamada, K., Tachibana, H., & Kawahara, H. (2013). Anti-allergic effect of strawberry extract. Journal of Functional Foods, 5(4), 1947-1955. https://doi.org/10.1016/j.jff.2013.09.016

Anti-allergic effect of strawberry extract. / Iwamoto, Akira; Inoue, Aiko; Inoue, Yuichi; Yamada, Koji; Tachibana, Hirofumi; Kawahara, Hiroharu.

In: Journal of Functional Foods, Vol. 5, No. 4, 01.10.2013, p. 1947-1955.

Research output: Contribution to journalArticle

Iwamoto, A, Inoue, A, Inoue, Y, Yamada, K, Tachibana, H & Kawahara, H 2013, 'Anti-allergic effect of strawberry extract', Journal of Functional Foods, vol. 5, no. 4, pp. 1947-1955. https://doi.org/10.1016/j.jff.2013.09.016
Iwamoto A, Inoue A, Inoue Y, Yamada K, Tachibana H, Kawahara H. Anti-allergic effect of strawberry extract. Journal of Functional Foods. 2013 Oct 1;5(4):1947-1955. https://doi.org/10.1016/j.jff.2013.09.016
Iwamoto, Akira ; Inoue, Aiko ; Inoue, Yuichi ; Yamada, Koji ; Tachibana, Hirofumi ; Kawahara, Hiroharu. / Anti-allergic effect of strawberry extract. In: Journal of Functional Foods. 2013 ; Vol. 5, No. 4. pp. 1947-1955.
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