Anti-androgen effects of extracts and compounds from Ganoderma lucidum

Jie Liu, Sadaaki Tamura, Kenji Kurashiki, Kuniyoshi Shimizu, Kiyoshi Noda, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The 30% EtOH extracts of Ganoderma lucidum FR. KARST (Ganodermateceae) showed weak 5α-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.

Original languageEnglish
Pages (from-to)231-243
Number of pages13
JournalChemistry and Biodiversity
Volume6
Issue number2
DOIs
Publication statusPublished - Apr 20 2009

Fingerprint

Reishi
Androgen Antagonists
Cell proliferation
Androgen Receptors
Prostate
Prostatic Neoplasms
Lymph Nodes
Cell Proliferation
Androgens
Carcinoma
Testosterone
Rats
Oxidoreductases
Prostatic Hyperplasia
Growth
ganoderiol F

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

Cite this

Liu, J., Tamura, S., Kurashiki, K., Shimizu, K., Noda, K., Konishi, F., ... Kondo, R. (2009). Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Chemistry and Biodiversity, 6(2), 231-243. https://doi.org/10.1002/cbdv.200800019

Anti-androgen effects of extracts and compounds from Ganoderma lucidum. / Liu, Jie; Tamura, Sadaaki; Kurashiki, Kenji; Shimizu, Kuniyoshi; Noda, Kiyoshi; Konishi, Fumiko; Kumamoto, Shoichiro; Kondo, Ryuichiro.

In: Chemistry and Biodiversity, Vol. 6, No. 2, 20.04.2009, p. 231-243.

Research output: Contribution to journalArticle

Liu, J, Tamura, S, Kurashiki, K, Shimizu, K, Noda, K, Konishi, F, Kumamoto, S & Kondo, R 2009, 'Anti-androgen effects of extracts and compounds from Ganoderma lucidum', Chemistry and Biodiversity, vol. 6, no. 2, pp. 231-243. https://doi.org/10.1002/cbdv.200800019
Liu, Jie ; Tamura, Sadaaki ; Kurashiki, Kenji ; Shimizu, Kuniyoshi ; Noda, Kiyoshi ; Konishi, Fumiko ; Kumamoto, Shoichiro ; Kondo, Ryuichiro. / Anti-androgen effects of extracts and compounds from Ganoderma lucidum. In: Chemistry and Biodiversity. 2009 ; Vol. 6, No. 2. pp. 231-243.
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