Anti-androgen effects of extracts and compounds from Ganoderma lucidum

Jie Liu, Sadaaki Tamura, Kenji Kurashiki, Kuniyoshi Shimizu, Kiyoshi Noda, Fumiko Konishi, Shoichiro Kumamoto, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

The 30% EtOH extracts of Ganoderma lucidum FR. KARST (Ganodermateceae) showed weak 5α-reductase inhibitory activity and binding ability to androgen receptor. When LNCaP (lymph-node carcinoma of the prostate) cells were treated with the EtOH extracts, cell proliferation was inhibited. Treatment with the extracts significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that G. lucidum might be a useful ingredient in the treatment of androgen-induced diseases, such as benign prostatic hyperplasia or prostate cancer. From the 30% EtOH extracts, we isolated ganoderiol F, which showed binding activity to androgen receptor and inhibited LNCaP cell proliferation, as one of the active compounds in the 30% EtOH extracts.

Original languageEnglish
Pages (from-to)231-243
Number of pages13
JournalChemistry and Biodiversity
Volume6
Issue number2
DOIs
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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