Anti-androgenic activities of Ganoderma lucidum

Rumi Fujita, Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Chie Ueda, Hisatoshi Tajiri, Shuhei Kaneko, Yoshitaro Suimi, Ryuichiro Kondo

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalJournal of Ethnopharmacology
Volume102
Issue number1
DOIs
Publication statusPublished - Oct 31 2005

Fingerprint

Reishi
Oxidoreductases
Agaricales
Prostatic Hyperplasia
Methanol
Testosterone
Prostate
Fruit
Growth

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

Fujita, R., Liu, J., Shimizu, K., Konishi, F., Noda, K., Kumamoto, S., ... Kondo, R. (2005). Anti-androgenic activities of Ganoderma lucidum. Journal of Ethnopharmacology, 102(1), 107-112. https://doi.org/10.1016/j.jep.2005.05.041

Anti-androgenic activities of Ganoderma lucidum. / Fujita, Rumi; Liu, Jie; Shimizu, Kuniyoshi; Konishi, Fumiko; Noda, Kiyoshi; Kumamoto, Shoichiro; Ueda, Chie; Tajiri, Hisatoshi; Kaneko, Shuhei; Suimi, Yoshitaro; Kondo, Ryuichiro.

In: Journal of Ethnopharmacology, Vol. 102, No. 1, 31.10.2005, p. 107-112.

Research output: Contribution to journalArticle

Fujita, R, Liu, J, Shimizu, K, Konishi, F, Noda, K, Kumamoto, S, Ueda, C, Tajiri, H, Kaneko, S, Suimi, Y & Kondo, R 2005, 'Anti-androgenic activities of Ganoderma lucidum', Journal of Ethnopharmacology, vol. 102, no. 1, pp. 107-112. https://doi.org/10.1016/j.jep.2005.05.041
Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S et al. Anti-androgenic activities of Ganoderma lucidum. Journal of Ethnopharmacology. 2005 Oct 31;102(1):107-112. https://doi.org/10.1016/j.jep.2005.05.041
Fujita, Rumi ; Liu, Jie ; Shimizu, Kuniyoshi ; Konishi, Fumiko ; Noda, Kiyoshi ; Kumamoto, Shoichiro ; Ueda, Chie ; Tajiri, Hisatoshi ; Kaneko, Shuhei ; Suimi, Yoshitaro ; Kondo, Ryuichiro. / Anti-androgenic activities of Ganoderma lucidum. In: Journal of Ethnopharmacology. 2005 ; Vol. 102, No. 1. pp. 107-112.
@article{2e904455085b40a0859c01e0c05537f2,
title = "Anti-androgenic activities of Ganoderma lucidum",
abstract = "The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).",
author = "Rumi Fujita and Jie Liu and Kuniyoshi Shimizu and Fumiko Konishi and Kiyoshi Noda and Shoichiro Kumamoto and Chie Ueda and Hisatoshi Tajiri and Shuhei Kaneko and Yoshitaro Suimi and Ryuichiro Kondo",
year = "2005",
month = "10",
day = "31",
doi = "10.1016/j.jep.2005.05.041",
language = "English",
volume = "102",
pages = "107--112",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Anti-androgenic activities of Ganoderma lucidum

AU - Fujita, Rumi

AU - Liu, Jie

AU - Shimizu, Kuniyoshi

AU - Konishi, Fumiko

AU - Noda, Kiyoshi

AU - Kumamoto, Shoichiro

AU - Ueda, Chie

AU - Tajiri, Hisatoshi

AU - Kaneko, Shuhei

AU - Suimi, Yoshitaro

AU - Kondo, Ryuichiro

PY - 2005/10/31

Y1 - 2005/10/31

N2 - The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

AB - The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

UR - http://www.scopus.com/inward/record.url?scp=25444516274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25444516274&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2005.05.041

DO - 10.1016/j.jep.2005.05.041

M3 - Article

C2 - 16029938

AN - SCOPUS:25444516274

VL - 102

SP - 107

EP - 112

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 1

ER -