Anti-androgenic activities of Ganoderma lucidum

Rumi Fujita; Jie Liu; Kuniyoshi Shimizu; Fumiko Konishi; Kiyoshi Noda; Shoichiro Kumamoto; Chie Ueda; Hisatoshi Tajiri; Shuhei Kaneko; Yoshitaro Suimi; Ryuichiro Kondo

doi:10.1016/j.jep.2005.05.041

Anti-androgenic activities of Ganoderma lucidum

Rumi Fujita, Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Chie Ueda, Hisatoshi Tajiri, Shuhei Kaneko, Yoshitaro Suimi, Ryuichiro Kondo

Sustainable Bioresources Science

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

Original language	English
Pages (from-to)	107-112
Number of pages	6
Journal	Journal of Ethnopharmacology
Volume	102
Issue number	1
DOIs	https://doi.org/10.1016/j.jep.2005.05.041
Publication status	Published - Oct 31 2005

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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abstract = "The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).",

author = "Rumi Fujita and Jie Liu and Kuniyoshi Shimizu and Fumiko Konishi and Kiyoshi Noda and Shoichiro Kumamoto and Chie Ueda and Hisatoshi Tajiri and Shuhei Kaneko and Yoshitaro Suimi and Ryuichiro Kondo",

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T1 - Anti-androgenic activities of Ganoderma lucidum

AU - Fujita, Rumi

AU - Liu, Jie

AU - Shimizu, Kuniyoshi

AU - Konishi, Fumiko

AU - Noda, Kiyoshi

AU - Kumamoto, Shoichiro

AU - Ueda, Chie

AU - Tajiri, Hisatoshi

AU - Kaneko, Shuhei

AU - Suimi, Yoshitaro

AU - Kondo, Ryuichiro

PY - 2005/10/31

Y1 - 2005/10/31

N2 - The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

AB - The inhibitory effects of methanol extracts of 19 edible and medicinal mushrooms on 5α-reductase activity were examined. The extract of Ganoderma lucidum Fr. Krast (Ganodermataceae) showed the strongest 5α-reductase inhibitory activity. The treatment of the fruit body of Ganoderma lucidum or the extract prepared from it significantly inhibited the testosterone-induced growth of the ventral prostate in castrated rats. These results showed that Ganoderma lucidum might be a useful ingredient for the treatment of benign prostatic hyperplasia (BPH).

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Anti-androgenic activities of Ganoderma lucidum

Abstract

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