Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Kenji Kurashiki, Ryuichiro Kondo

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49 Citations (Scopus)

Abstract

The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

Original languageEnglish
Pages (from-to)1691-1696
Number of pages6
JournalFood Chemistry
Volume100
Issue number4
DOIs
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

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    Liu, J., Shimizu, K., Konishi, F., Noda, K., Kumamoto, S., Kurashiki, K., & Kondo, R. (2007). Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum. Food Chemistry, 100(4), 1691-1696. https://doi.org/10.1016/j.foodchem.2006.01.003