Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Kenji Kurashiki, Ryuichiro Kondo

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

Original languageEnglish
Pages (from-to)1691-1696
Number of pages6
JournalFood Chemistry
Volume100
Issue number4
DOIs
Publication statusPublished - Jan 1 2007

Fingerprint

Reishi
Ganoderma lucidum
Dihydrotestosterone
Fractionation
triterpenoids
Isoenzymes
Testosterone
Rats
Oxidoreductases
Ethanol
Prostatic Hyperplasia
hyperplasia
testosterone
isozymes
Prostate
fractionation
ingredients
ethanol
rats
extracts

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science

Cite this

Liu, J., Shimizu, K., Konishi, F., Noda, K., Kumamoto, S., Kurashiki, K., & Kondo, R. (2007). Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum. Food Chemistry, 100(4), 1691-1696. https://doi.org/10.1016/j.foodchem.2006.01.003

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum. / Liu, Jie; Shimizu, Kuniyoshi; Konishi, Fumiko; Noda, Kiyoshi; Kumamoto, Shoichiro; Kurashiki, Kenji; Kondo, Ryuichiro.

In: Food Chemistry, Vol. 100, No. 4, 01.01.2007, p. 1691-1696.

Research output: Contribution to journalArticle

Liu, J, Shimizu, K, Konishi, F, Noda, K, Kumamoto, S, Kurashiki, K & Kondo, R 2007, 'Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum', Food Chemistry, vol. 100, no. 4, pp. 1691-1696. https://doi.org/10.1016/j.foodchem.2006.01.003
Liu, Jie ; Shimizu, Kuniyoshi ; Konishi, Fumiko ; Noda, Kiyoshi ; Kumamoto, Shoichiro ; Kurashiki, Kenji ; Kondo, Ryuichiro. / Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum. In: Food Chemistry. 2007 ; Vol. 100, No. 4. pp. 1691-1696.
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