Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu; Kuniyoshi Shimizu; Fumiko Konishi; Kiyoshi Noda; Shoichiro Kumamoto; Kenji Kurashiki; Ryuichiro Kondo

doi:10.1016/j.foodchem.2006.01.003

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Kenji Kurashiki, Ryuichiro Kondo

Sustainable Bioresources Science

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

Original language	English
Pages (from-to)	1691-1696
Number of pages	6
Journal	Food Chemistry
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/j.foodchem.2006.01.003
Publication status	Published - 2007

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Food Science

Access to Document

10.1016/j.foodchem.2006.01.003

Cite this

@article{5226e7123394427db8608bf66285bb8c,

title = "Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum",

abstract = "The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.",

author = "Jie Liu and Kuniyoshi Shimizu and Fumiko Konishi and Kiyoshi Noda and Shoichiro Kumamoto and Kenji Kurashiki and Ryuichiro Kondo",

year = "2007",

doi = "10.1016/j.foodchem.2006.01.003",

language = "English",

volume = "100",

pages = "1691--1696",

journal = "Food Chemistry",

issn = "0308-8146",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

AU - Liu, Jie

AU - Shimizu, Kuniyoshi

AU - Konishi, Fumiko

AU - Noda, Kiyoshi

AU - Kumamoto, Shoichiro

AU - Kurashiki, Kenji

AU - Kondo, Ryuichiro

PY - 2007

Y1 - 2007

N2 - The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

AB - The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

UR - http://www.scopus.com/inward/record.url?scp=33746522974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746522974&partnerID=8YFLogxK

U2 - 10.1016/j.foodchem.2006.01.003

DO - 10.1016/j.foodchem.2006.01.003

M3 - Article

AN - SCOPUS:33746522974

SN - 0308-8146

VL - 100

SP - 1691

EP - 1696

JO - Food Chemistry

JF - Food Chemistry

IS - 4

ER -

Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this