Anti-androgenic activities of the triterpenoids fraction of Ganoderma lucidum

Jie Liu, Kuniyoshi Shimizu, Fumiko Konishi, Kiyoshi Noda, Shoichiro Kumamoto, Kenji Kurashiki, Ryuichiro Kondo

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.

Original languageEnglish
Pages (from-to)1691-1696
Number of pages6
JournalFood Chemistry
Issue number4
Publication statusPublished - 2007

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Food Science


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