TY - JOUR
T1 - Anti-cancer effect of EGCG and its mechanisms
AU - Kumazoe, Motofumi
AU - Tachibana, Hirofumi
N1 - Funding Information:
Acknowledgments: This work was supported in part by JSPS KAKENHI grant 22228002 and 15H02448 to H. Tachibana and M. Kumazoe 15K18821. The pictures were drawn by Kanako Takamatsu. The authors declare no competing financial interests.
Publisher Copyright:
© 2016 Functional Foods in Health and Disease. All rights reserved.
PY - 2016/2
Y1 - 2016/2
N2 - Background: Epidemiological analysis demonstrated that there are negative correlation between green tea consumption and the risk of non-Hodgkin lymphoma and prostate cancer. Recent studies show (–)-epigallocatechin-3-O-gallate (EGCG), or major green tea polyphenol, suppresses the proliferation of cancer cells and induces cell death without adversely affecting normal cells. As a result, several molecular mechanisms have been suggested to be responsible for this effect. For example, 67-kDa laminin receptor (67LR) was recently identified as the sensing molecule for EGCG. 67LR overexpresses in cancer cells and plays a crucial role in the selective toxicity of EGCG. Moreover, possible downstream mechanisms were suggested in 67LR-dependent the anti-cancer effect of EGCG. This review focused on the molecular mechanism of EGCG and developing a novel strategy to amplify its effect.
AB - Background: Epidemiological analysis demonstrated that there are negative correlation between green tea consumption and the risk of non-Hodgkin lymphoma and prostate cancer. Recent studies show (–)-epigallocatechin-3-O-gallate (EGCG), or major green tea polyphenol, suppresses the proliferation of cancer cells and induces cell death without adversely affecting normal cells. As a result, several molecular mechanisms have been suggested to be responsible for this effect. For example, 67-kDa laminin receptor (67LR) was recently identified as the sensing molecule for EGCG. 67LR overexpresses in cancer cells and plays a crucial role in the selective toxicity of EGCG. Moreover, possible downstream mechanisms were suggested in 67LR-dependent the anti-cancer effect of EGCG. This review focused on the molecular mechanism of EGCG and developing a novel strategy to amplify its effect.
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U2 - 10.31989/ffhd.v6i2.239
DO - 10.31989/ffhd.v6i2.239
M3 - Article
AN - SCOPUS:85032275581
SN - 2378-7007
VL - 6
SP - 70
EP - 78
JO - Functional Foods in Health and Disease
JF - Functional Foods in Health and Disease
IS - 2
ER -
