Anti-CXCR3 staining is useful for detecting human cutaneous and mucosal mast cells

Noriko Fukiwake, Yoichi Moroi, Shinichi Imafuku, Teiichi Masuda, Hisashi Kokuba, Masutaka Furue, Kazunori Urabe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Human synovial mast cells (MC) can be immunolabelled with antihuman CXCR3 antibody (Ab) (clone 49801). We have investigated whether cutaneous and mucosal MC are stained with anti-CXCR3 Ab in paraffin-embedded sections. Immunohistochemical staining and immunofluorescence double staining assays were performed with anti-CXCR3, anti-tryptase, and anti-chymase Ab using normal skin, psoriatic skin lesions, and normal colon. When compared with tryptase and chymase staining, 100% of the cutaneous and 98% of the mucosal MC were positive for CXCR3. Anti-CXCR3 staining is a useful marker for human cutaneous and mucosal MC in paraffin-embedded sections.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalJournal of Dermatology
Volume33
Issue number5
DOIs
Publication statusPublished - May 2006

All Science Journal Classification (ASJC) codes

  • Dermatology

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