Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis

Tomoya Shibahara, Tomonaga Matsushita, Ryu Matsuo, Yoshihisa Fukushima, Kenji Fukuda, Hiroshi Sugimori, Masahiro Kamouchi, Takanari Kitazono, Tetsuro Ago

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Rheumatoid meningoencephalitis (RM) is a rare complication of rheumatoid arthritis (RA). This report describes a 63-year-old man with complaints of high-grade fever, headache, and vomiting for several days before admission. Both his serum and cerebrospinal fluid were positive for anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor, and contrast-enhanced fluid-attenuated inversion recovery magnetic resonance imaging (MRI) showed abnormal gadolinium enhancement of the meninges and high-intensity lesions in the subarachnoid spaces. The patient was diagnosed with RM despite lack of signs suggesting RA. His symptoms drastically improved with intravenous infusion of high-dose methylprednisolone. Two months later, he developed RA. The findings in this patient suggest that RM could develop prior to the onset of RA. Anti-CCP antibody and MRI findings may be useful for the diagnosis of RM, regardless of RA history.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalCase Reports in Neurology
Volume8
Issue number2
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Meningoencephalitis
Rheumatoid Arthritis
Antibodies
Magnetic Resonance Imaging
Meninges
Subarachnoid Space
Rheumatoid Factor
Methylprednisolone
Gadolinium
Intravenous Infusions
Vomiting
Headache
Cerebrospinal Fluid
Fever
cyclic citrullinated peptide
Serum

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis. / Shibahara, Tomoya; Matsushita, Tomonaga; Matsuo, Ryu; Fukushima, Yoshihisa; Fukuda, Kenji; Sugimori, Hiroshi; Kamouchi, Masahiro; Kitazono, Takanari; Ago, Tetsuro.

In: Case Reports in Neurology, Vol. 8, No. 2, 01.01.2016, p. 156-160.

Research output: Contribution to journalArticle

Shibahara, Tomoya ; Matsushita, Tomonaga ; Matsuo, Ryu ; Fukushima, Yoshihisa ; Fukuda, Kenji ; Sugimori, Hiroshi ; Kamouchi, Masahiro ; Kitazono, Takanari ; Ago, Tetsuro. / Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis. In: Case Reports in Neurology. 2016 ; Vol. 8, No. 2. pp. 156-160.
@article{1592d6434c8248909a88c9212eae1075,
title = "Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis",
abstract = "Rheumatoid meningoencephalitis (RM) is a rare complication of rheumatoid arthritis (RA). This report describes a 63-year-old man with complaints of high-grade fever, headache, and vomiting for several days before admission. Both his serum and cerebrospinal fluid were positive for anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor, and contrast-enhanced fluid-attenuated inversion recovery magnetic resonance imaging (MRI) showed abnormal gadolinium enhancement of the meninges and high-intensity lesions in the subarachnoid spaces. The patient was diagnosed with RM despite lack of signs suggesting RA. His symptoms drastically improved with intravenous infusion of high-dose methylprednisolone. Two months later, he developed RA. The findings in this patient suggest that RM could develop prior to the onset of RA. Anti-CCP antibody and MRI findings may be useful for the diagnosis of RM, regardless of RA history.",
author = "Tomoya Shibahara and Tomonaga Matsushita and Ryu Matsuo and Yoshihisa Fukushima and Kenji Fukuda and Hiroshi Sugimori and Masahiro Kamouchi and Takanari Kitazono and Tetsuro Ago",
year = "2016",
month = "1",
day = "1",
doi = "10.1159/000447627",
language = "English",
volume = "8",
pages = "156--160",
journal = "Case Reports in Neurology",
issn = "1662-680X",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Anti-Cyclic Citrullinated Peptide Antibody-Positive Meningoencephalitis in the Preclinical Period of Rheumatoid Arthritis

AU - Shibahara, Tomoya

AU - Matsushita, Tomonaga

AU - Matsuo, Ryu

AU - Fukushima, Yoshihisa

AU - Fukuda, Kenji

AU - Sugimori, Hiroshi

AU - Kamouchi, Masahiro

AU - Kitazono, Takanari

AU - Ago, Tetsuro

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Rheumatoid meningoencephalitis (RM) is a rare complication of rheumatoid arthritis (RA). This report describes a 63-year-old man with complaints of high-grade fever, headache, and vomiting for several days before admission. Both his serum and cerebrospinal fluid were positive for anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor, and contrast-enhanced fluid-attenuated inversion recovery magnetic resonance imaging (MRI) showed abnormal gadolinium enhancement of the meninges and high-intensity lesions in the subarachnoid spaces. The patient was diagnosed with RM despite lack of signs suggesting RA. His symptoms drastically improved with intravenous infusion of high-dose methylprednisolone. Two months later, he developed RA. The findings in this patient suggest that RM could develop prior to the onset of RA. Anti-CCP antibody and MRI findings may be useful for the diagnosis of RM, regardless of RA history.

AB - Rheumatoid meningoencephalitis (RM) is a rare complication of rheumatoid arthritis (RA). This report describes a 63-year-old man with complaints of high-grade fever, headache, and vomiting for several days before admission. Both his serum and cerebrospinal fluid were positive for anti-cyclic citrullinated peptide (CCP) antibody and rheumatoid factor, and contrast-enhanced fluid-attenuated inversion recovery magnetic resonance imaging (MRI) showed abnormal gadolinium enhancement of the meninges and high-intensity lesions in the subarachnoid spaces. The patient was diagnosed with RM despite lack of signs suggesting RA. His symptoms drastically improved with intravenous infusion of high-dose methylprednisolone. Two months later, he developed RA. The findings in this patient suggest that RM could develop prior to the onset of RA. Anti-CCP antibody and MRI findings may be useful for the diagnosis of RM, regardless of RA history.

UR - http://www.scopus.com/inward/record.url?scp=84979080408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979080408&partnerID=8YFLogxK

U2 - 10.1159/000447627

DO - 10.1159/000447627

M3 - Article

AN - SCOPUS:84979080408

VL - 8

SP - 156

EP - 160

JO - Case Reports in Neurology

JF - Case Reports in Neurology

SN - 1662-680X

IS - 2

ER -