Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren's syndrome

Marie Satake, Takeo Yoshimura, Toru Iwaki, Takeshi Yamada, Takuro Kobayashi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report the case of a 59-year-old woman with primary Sjögren's syndrome who developed hypesthesia, hypalgesia, and neurogenic arthropathy in her lower limbs. Neurological examination and electrophysiological studies indicated involvement of the dorsal root ganglia. The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves. These results, consistent with particular impairment of pain and touch senses, suggest that dorsal root ganglionitis in primary Sjögren's syndrome is mediated by humoral autoimmunity.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalJournal of the Neurological Sciences
Volume132
Issue number2
DOIs
Publication statusPublished - Oct 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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