Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren's syndrome

Marie Satake, Takeo Yoshimura, Toru Iwaki, Takeshi Yamada, Takuro Kobayashi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report the case of a 59-year-old woman with primary Sjögren's syndrome who developed hypesthesia, hypalgesia, and neurogenic arthropathy in her lower limbs. Neurological examination and electrophysiological studies indicated involvement of the dorsal root ganglia. The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves. These results, consistent with particular impairment of pain and touch senses, suggest that dorsal root ganglionitis in primary Sjögren's syndrome is mediated by humoral autoimmunity.

Original languageEnglish
Pages (from-to)122-125
Number of pages4
JournalJournal of the Neurological Sciences
Volume132
Issue number2
DOIs
Publication statusPublished - Oct 1995
Externally publishedYes

Fingerprint

Spinal Nerve Roots
Spinal Ganglia
Neurons
Antibodies
Neurogenic Arthropathy
Hypesthesia
Neurologic Examination
Touch
Autoimmunity
Peripheral Nerves
Cerebellum
Cerebrospinal Fluid
Lower Extremity
Immunoglobulin G
Immunohistochemistry
Pain
Serum

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren's syndrome. / Satake, Marie; Yoshimura, Takeo; Iwaki, Toru; Yamada, Takeshi; Kobayashi, Takuro.

In: Journal of the Neurological Sciences, Vol. 132, No. 2, 10.1995, p. 122-125.

Research output: Contribution to journalArticle

Satake, Marie ; Yoshimura, Takeo ; Iwaki, Toru ; Yamada, Takeshi ; Kobayashi, Takuro. / Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren's syndrome. In: Journal of the Neurological Sciences. 1995 ; Vol. 132, No. 2. pp. 122-125.
@article{318da331eec548a3bee69a0fb1fbb83a,
title = "Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sj{\"o}gren's syndrome",
abstract = "We report the case of a 59-year-old woman with primary Sj{\"o}gren's syndrome who developed hypesthesia, hypalgesia, and neurogenic arthropathy in her lower limbs. Neurological examination and electrophysiological studies indicated involvement of the dorsal root ganglia. The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves. These results, consistent with particular impairment of pain and touch senses, suggest that dorsal root ganglionitis in primary Sj{\"o}gren's syndrome is mediated by humoral autoimmunity.",
author = "Marie Satake and Takeo Yoshimura and Toru Iwaki and Takeshi Yamada and Takuro Kobayashi",
year = "1995",
month = "10",
doi = "10.1016/0022-510X(95)00134-N",
language = "English",
volume = "132",
pages = "122--125",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Anti-dorsal root ganglion neuron antibody in a case of dorsal root ganglionitis associated with Sjögren's syndrome

AU - Satake, Marie

AU - Yoshimura, Takeo

AU - Iwaki, Toru

AU - Yamada, Takeshi

AU - Kobayashi, Takuro

PY - 1995/10

Y1 - 1995/10

N2 - We report the case of a 59-year-old woman with primary Sjögren's syndrome who developed hypesthesia, hypalgesia, and neurogenic arthropathy in her lower limbs. Neurological examination and electrophysiological studies indicated involvement of the dorsal root ganglia. The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves. These results, consistent with particular impairment of pain and touch senses, suggest that dorsal root ganglionitis in primary Sjögren's syndrome is mediated by humoral autoimmunity.

AB - We report the case of a 59-year-old woman with primary Sjögren's syndrome who developed hypesthesia, hypalgesia, and neurogenic arthropathy in her lower limbs. Neurological examination and electrophysiological studies indicated involvement of the dorsal root ganglia. The immunohistochemistry of sections of rat dorsal root ganglion (DRG) showed that the IgG in the serum and cerebrospinal fluid (CSF) from the patient bound to the neuronal perikarya of small DRG neurons but not to the cerebellum or peripheral nerves. These results, consistent with particular impairment of pain and touch senses, suggest that dorsal root ganglionitis in primary Sjögren's syndrome is mediated by humoral autoimmunity.

UR - http://www.scopus.com/inward/record.url?scp=0029120643&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029120643&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(95)00134-N

DO - 10.1016/0022-510X(95)00134-N

M3 - Article

C2 - 8543935

AN - SCOPUS:0029120643

VL - 132

SP - 122

EP - 125

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 2

ER -