TY - JOUR
T1 - Anti-obesity activity of Yamabushitake (Hericium erinaceus) powder in ovariectomized mice, and its potentially active compounds
AU - Hiraki, Eri
AU - Furuta, Shoko
AU - Kuwahara, Rika
AU - Takemoto, Naomichi
AU - Nagata, Toshiro
AU - Akasaka, Taiki
AU - Shirouchi, Bungo
AU - Sato, Masao
AU - Ohnuki, Koichiro
AU - Shimizu, Kuniyoshi
N1 - Publisher Copyright:
© 2017, The Japanese Society of Pharmacognosy and Springer Japan.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids.
AB - Hericium erinaceus (H. erinaceus) improves the symptoms of menopause. In this study, using ovariectomized mice as a model of menopause, we investigated the anti-obesity effect of this mushroom in menopause. Mice fed diets containing H. erinaceus powder showed significant decreases in the amounts of fat tissue, plasma levels of total cholesterol, and leptin. To determine the mechanism, groups of mice were respectively fed a diet containing H. erinaceus powder, a diet containing ethanol extract of H. erinaceus, and a diet containing a residue of the extract. As a result, H. erinaceus powder was found to increase fecal lipid levels in excreted matter. Further in vitro investigation showed that ethanol extract inhibited the activity of lipase, and four lipase-inhibitory compounds were isolated from the extract: hericenone C, hericenone D, hericenone F, and hericenone G. In short, we suggest that H. erinaceus has an anti-obesity effect during menopause because it decreases the ability to absorb lipids.
UR - http://www.scopus.com/inward/record.url?scp=85011850253&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85011850253&partnerID=8YFLogxK
U2 - 10.1007/s11418-017-1075-8
DO - 10.1007/s11418-017-1075-8
M3 - Article
C2 - 28181079
AN - SCOPUS:85011850253
VL - 71
SP - 482
EP - 491
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1340-3443
IS - 3
ER -