Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders

Mitsuru Watanabe, Takayuki Kondo, Kenji Murakata, Takashi Kageyama, Yoko Shibata, Toshiyuki Takahashi, Kyoichi Nomura, Sadayuki Matsumoto

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5 Citations (Scopus)

Abstract

Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti. N-methyl. d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of Neuroimmunology
Volume274
Issue number1-2
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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    Watanabe, M., Kondo, T., Murakata, K., Kageyama, T., Shibata, Y., Takahashi, T., Nomura, K., & Matsumoto, S. (2014). Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders. Journal of Neuroimmunology, 274(1-2), 155-160. https://doi.org/10.1016/j.jneuroim.2014.06.020