Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders

mitsuru watanabe, Takayuki Kondo, Kenji Murakata, Takashi Kageyama, Yoko Shibata, Toshiyuki Takahashi, Kyoichi Nomura, Sadayuki Matsumoto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Anti-aquaporin 4 (AQP4) antibodies (Abs) are essential in neuromyelitis optica spectrum disorders (NMOSD), but the relationship between CNS demyelinating disorders (CNSDD) and other neural Abs remains unclear. Here we screened anti-neural Abs in the sera of 70 Japanese CNSDD patients. While two had only demyelinating events among three anti. N-methyl. d-aspartate receptor (NMDAR) Ab-positive subjects, the other subject who also had anti-AQP4 Abs experienced episodes of anti-NMDAR encephalitis and of NMOSD. Major lesions in the three anti-contactin-associated protein 2 Ab-positive subjects were infratentorial, including one co-carrying anti-AQP4 Abs. Thus, autoantibodies can be clinically silent, but multiple autoantibodies may participate in the pathogenesis.

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalJournal of Neuroimmunology
Volume274
Issue number1-2
DOIs
Publication statusPublished - Jan 1 2014

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Autoantigens
Demyelinating Diseases
Aquaporin 4
Neuromyelitis Optica
Antibodies
Autoantibodies
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Contactins
Anti-Idiotypic Antibodies
Serum
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders. / watanabe, mitsuru; Kondo, Takayuki; Murakata, Kenji; Kageyama, Takashi; Shibata, Yoko; Takahashi, Toshiyuki; Nomura, Kyoichi; Matsumoto, Sadayuki.

In: Journal of Neuroimmunology, Vol. 274, No. 1-2, 01.01.2014, p. 155-160.

Research output: Contribution to journalArticle

watanabe, M, Kondo, T, Murakata, K, Kageyama, T, Shibata, Y, Takahashi, T, Nomura, K & Matsumoto, S 2014, 'Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders', Journal of Neuroimmunology, vol. 274, no. 1-2, pp. 155-160. https://doi.org/10.1016/j.jneuroim.2014.06.020
watanabe, mitsuru ; Kondo, Takayuki ; Murakata, Kenji ; Kageyama, Takashi ; Shibata, Yoko ; Takahashi, Toshiyuki ; Nomura, Kyoichi ; Matsumoto, Sadayuki. / Antibodies to neural and non-neural autoantigens in Japanese patients with CNS demyelinating disorders. In: Journal of Neuroimmunology. 2014 ; Vol. 274, No. 1-2. pp. 155-160.
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