Antibody internalization into living cells via crosslinker-mediated endocytosis

Daiki Funamoto, Daisuke Asai, Kazuki Sato, Yoko Yamaguchi, Chan Woo Kim, Hikari Sato, Elnaz Nakhaei, Shingo Matsumoto, Takuma Yoshikawa, Koichi Sasaki, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticle

Abstract

We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalChemistry Letters
Volume44
Issue number4
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Antibody internalization into living cells via crosslinker-mediated endocytosis'. Together they form a unique fingerprint.

  • Cite this

    Funamoto, D., Asai, D., Sato, K., Yamaguchi, Y., Kim, C. W., Sato, H., Nakhaei, E., Matsumoto, S., Yoshikawa, T., Sasaki, K., Yamamoto, T., Kishimura, A., Mori, T., & Katayama, Y. (2015). Antibody internalization into living cells via crosslinker-mediated endocytosis. Chemistry Letters, 44(4), 468-470. https://doi.org/10.1246/cl.141157