Antibody internalization into living cells via crosslinker-mediated endocytosis

Daiki Funamoto, Daisuke Asai, Kazuki Sato, Yoko Yamaguchi, Chan Woo Kim, Hikari Sato, Elnaz Nakhaei, Shingo Matsumoto, Takuma Yoshikawa, Koichi Sasaki, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama

Research output: Contribution to journalArticle

Abstract

We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This cross-linker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

Original languageEnglish
Pages (from-to)468-470
Number of pages3
JournalChemistry Letters
Volume44
Issue number4
DOIs
Publication statusPublished - Jan 1 2015

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Folic Acid
Cells
Antibodies
Immunoglobulin G
Ligands
Peptides

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Funamoto, D., Asai, D., Sato, K., Yamaguchi, Y., Kim, C. W., Sato, H., ... Katayama, Y. (2015). Antibody internalization into living cells via crosslinker-mediated endocytosis. Chemistry Letters, 44(4), 468-470. https://doi.org/10.1246/cl.141157

Antibody internalization into living cells via crosslinker-mediated endocytosis. / Funamoto, Daiki; Asai, Daisuke; Sato, Kazuki; Yamaguchi, Yoko; Kim, Chan Woo; Sato, Hikari; Nakhaei, Elnaz; Matsumoto, Shingo; Yoshikawa, Takuma; Sasaki, Koichi; Yamamoto, Tatsuhiro; Kishimura, Akihiro; Mori, Takeshi; Katayama, Yoshiki.

In: Chemistry Letters, Vol. 44, No. 4, 01.01.2015, p. 468-470.

Research output: Contribution to journalArticle

Funamoto, D, Asai, D, Sato, K, Yamaguchi, Y, Kim, CW, Sato, H, Nakhaei, E, Matsumoto, S, Yoshikawa, T, Sasaki, K, Yamamoto, T, Kishimura, A, Mori, T & Katayama, Y 2015, 'Antibody internalization into living cells via crosslinker-mediated endocytosis', Chemistry Letters, vol. 44, no. 4, pp. 468-470. https://doi.org/10.1246/cl.141157
Funamoto D, Asai D, Sato K, Yamaguchi Y, Kim CW, Sato H et al. Antibody internalization into living cells via crosslinker-mediated endocytosis. Chemistry Letters. 2015 Jan 1;44(4):468-470. https://doi.org/10.1246/cl.141157
Funamoto, Daiki ; Asai, Daisuke ; Sato, Kazuki ; Yamaguchi, Yoko ; Kim, Chan Woo ; Sato, Hikari ; Nakhaei, Elnaz ; Matsumoto, Shingo ; Yoshikawa, Takuma ; Sasaki, Koichi ; Yamamoto, Tatsuhiro ; Kishimura, Akihiro ; Mori, Takeshi ; Katayama, Yoshiki. / Antibody internalization into living cells via crosslinker-mediated endocytosis. In: Chemistry Letters. 2015 ; Vol. 44, No. 4. pp. 468-470.
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