Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years

Shigeki Nabeshima, Kenichiro Kashiwagi, Murata Masayuki, Yoko Kanamoto, Norihiro Furusyo, Jun Hayashi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Fifty seven hospital workers received influenza vaccine in November 2003, and the serum HI antibody titer was determined before, 2 and 4 weeks after the vaccination. Thirty seven were vaccinated in November, 2002 consecutively (the repeated vaccination group), and the remaining 20 had not been vaccinated in the previous year (the single vaccination group). Six of the repeated vaccination group received both influenza and hepatitis B vaccination in September, 2004 and the antibody responses were examined 2 weeks later. Two and four weeks after the 2003-vaccination, the HI antibody titers to A/ H1N1, A/H3N2, and B in the repeated vaccination group were significantly lower than in the single vaccination group (P < 0.05). This phenomenon had no relation to the pre-vaccination HI antibody titer. The antibody response was low to repeated influenza vaccination, but normal to hepatitis B vaccine in six subjects who had a second vaccination in 2004, showing that this depressed response was influenza-specific. These results suggest that the decreased HI antibody response to repeated influenza vaccination was affected mainly by the previous vaccination per se rather than by the pre-existing antibody titer.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalJournal of Medical Virology
Volume79
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

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Influenza Vaccines
Antibody Formation
Vaccination
Vaccines
Human Influenza
Antibodies
Hepatitis B Vaccines
Hepatitis B

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. / Nabeshima, Shigeki; Kashiwagi, Kenichiro; Masayuki, Murata; Kanamoto, Yoko; Furusyo, Norihiro; Hayashi, Jun.

In: Journal of Medical Virology, Vol. 79, No. 3, 01.03.2007, p. 320-325.

Research output: Contribution to journalArticle

Nabeshima, Shigeki ; Kashiwagi, Kenichiro ; Masayuki, Murata ; Kanamoto, Yoko ; Furusyo, Norihiro ; Hayashi, Jun. / Antibody response to influenza vaccine in adults vaccinated with identical vaccine strains in consecutive years. In: Journal of Medical Virology. 2007 ; Vol. 79, No. 3. pp. 320-325.
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