Anticarcinogenic effects of (-)-epigallocatechin gallate

Hirota Fujiki, Seiji Yoshizawa, Takahiko Horiuchi, Masami Suganuma, Jun Yatsunami, Shinji Nishiwaki, Sachiko Okabe, Rie Nishiwaki-Matsushima, Takuo Okuda, Takashi Sugimura

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120 Citations (Scopus)

Abstract

Background. Our research objective is to develop nontoxic cancer chemopreventive agents and to apply these agents in treating humans. We are identifying agents that inhibit the process of tumor promotion in two-stage carcinogenesis experiments on mouse skin. Methods. We review (a) the inhibitory effect of penta-O-galloyl-β-d-glucose (5GG) on tumor promotion by teleocidin, one of the 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters (5GG is structurally similar to (-)-epigallocatechin gallate (EGCG) and is isolated from hydrolyzed tannic acid); (b) the inhibitory effects of EGCG, the main constituent of Japanese green tea, on tumor promotion with two tumor promoters, teleocidin and okadaic acid, a non-TPA-type tumor promoter; (c) the mechanisms of action of EGCG, a single application of which reduced the specific binding of [3H]TPA and [3H]okadaic acid to a particulate fraction of mouse skin; and (d) the anticarcinogenic effects of EGCG on duodenal carcinogenesis induced by N-ethyl-N′-nitro-N-nitrosoguanidine in male C57BL/6 mice. EGCG is a nontoxic compound. Conclusion. We believe that the main constituent of Japanese green tea, EGCG, is a practical cancer chemopreventive agent available in everyday life.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalPreventive Medicine
Volume21
Issue number4
DOIs
Publication statusPublished - Jul 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

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    Fujiki, H., Yoshizawa, S., Horiuchi, T., Suganuma, M., Yatsunami, J., Nishiwaki, S., Okabe, S., Nishiwaki-Matsushima, R., Okuda, T., & Sugimura, T. (1992). Anticarcinogenic effects of (-)-epigallocatechin gallate. Preventive Medicine, 21(4), 503-509. https://doi.org/10.1016/0091-7435(92)90057-O