Antidepressant-like effect of bright light is potentiated by l-serine administration in a mouse model of seasonal affective disorder

Misato Kawai, Ryosei Goda, Tsuyoshi Otsuka, Ayaka Iwamoto, Nobuo Uotsu, Mitsuhiro Furuse, Shinobu Yasuo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bright light therapy is used as the primary treatment for seasonal affective disorder; however, the mechanisms underlying its antidepressant effect are not fully understood. Previously, we found that C57BL/6J mice exhibit increased depression-like behavior during a short-day condition (SD) and have lowered brain serotonin (5-HT) content. This study analyzed the effect of bright light on depression-like behaviors and the brain serotonergic system using the C57BL/6J mice. In the mice maintained under SD, bright light treatment (1000. lx, daily 1. h exposure) for 1 week reduced immobility time in the forced swimming test and increased intake of saccharin solution in a saccharin intake test. However, the light treatment did not modify 5-HT content and selective 5-HT uptake in the amygdala, or temporal patterns of core body temperature and wheel-running activity throughout a day. In the next experiment, we attempted to enhance the effect of bright light by using l-serine, a precursor of d-serine that acts as an N-methyl- d-aspartic acid receptor coagonist. Daily subcutaneous injection of l-serine for 2 weeks prior to the bright light strongly reduced the immobility time in the forced swimming test, suggesting a synergistic effect of light and l-serine. Furthermore, bright light increased the total number of 5-HT-immunoreactive cells and cells that had colocalized 5-HT and c-Fos immunosignals in several subregions of the raphe nuclei. These effects were potentiated by prior injection of l-serine. These data suggest that the bright light may elicit an antidepressant-like effect via enhanced 5-HT signals in the brain and l-serine can enhance these effects.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalBrain Research Bulletin
Volume118
DOIs
Publication statusPublished - Sep 1 2015

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Seasonal Affective Disorder
Serine
Antidepressive Agents
Serotonin
Light
Saccharin
Inbred C57BL Mouse
Brain
Depression
Raphe Nuclei
Phototherapy
Subcutaneous Injections
Amygdala
Body Temperature
Running
Therapeutics
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Antidepressant-like effect of bright light is potentiated by l-serine administration in a mouse model of seasonal affective disorder. / Kawai, Misato; Goda, Ryosei; Otsuka, Tsuyoshi; Iwamoto, Ayaka; Uotsu, Nobuo; Furuse, Mitsuhiro; Yasuo, Shinobu.

In: Brain Research Bulletin, Vol. 118, 01.09.2015, p. 25-33.

Research output: Contribution to journalArticle

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