Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia

Irawan Wijaya Kusuma, Enos Tangke Arung, Enih Rosamah, Sri Purwatiningsih, Harlinda Kuspradini, Syafrizal, Juli Astuti, Yong Ung Kim, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

An active compound from the bulb of Eleutherine americana L. Merr. (Iridaceae) collected from East Kalimantan, Indonesia, was tested for its antidermatophyte and antimelanogenesis activity. Antifungal assay-directed fractionation of the n-hexane-soluble fraction of the methanolic extract of the bulb of E. americana led to the isolation of 1 as an active compound. The compound was identified as the naphthoquinone eleutherin by EI-MS and 1H-, 13C-, and two-dimensional NMR analyses. Antidermatophyte assay of 1 at concentrations of 10, 20, 40, 60, and 80 μg/disk and myconazole, a commercial antidermatophyte, at 10 μg/disk displayed 7, 8, 13, 16, 17, and 14 mm of inhibition zone against Trichophyton mentagrophytes, respectively. In a melanin formation inhibition assay, compound 1 displayed potent antimelanogenesis activity at 5 ppm with low toxicity compared with arbutin, a commercial skin-whitening agent. The results showed the high potential of 1, an active compound from E. americana, to be applied as an antidermatophyte and antimelanogenesis agent.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalJournal of Natural Medicines
Volume64
Issue number2
DOIs
Publication statusPublished - Apr 1 2010

Fingerprint

Iridaceae
Skin Lightening Preparations
Arbutin
Naphthoquinones
Trichophyton
Indonesia
Melanins
Assays
Bleaching Agents
Fractionation
Toxicity
Skin
Nuclear magnetic resonance
eleutherin
n-hexane

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia. / Kusuma, Irawan Wijaya; Arung, Enos Tangke; Rosamah, Enih; Purwatiningsih, Sri; Kuspradini, Harlinda; Syafrizal; Astuti, Juli; Kim, Yong Ung; Shimizu, Kuniyoshi.

In: Journal of Natural Medicines, Vol. 64, No. 2, 01.04.2010, p. 223-226.

Research output: Contribution to journalArticle

Kusuma, IW, Arung, ET, Rosamah, E, Purwatiningsih, S, Kuspradini, H, Syafrizal, Astuti, J, Kim, YU & Shimizu, K 2010, 'Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia', Journal of Natural Medicines, vol. 64, no. 2, pp. 223-226. https://doi.org/10.1007/s11418-010-0396-7
Kusuma IW, Arung ET, Rosamah E, Purwatiningsih S, Kuspradini H, Syafrizal et al. Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia. Journal of Natural Medicines. 2010 Apr 1;64(2):223-226. https://doi.org/10.1007/s11418-010-0396-7
Kusuma, Irawan Wijaya ; Arung, Enos Tangke ; Rosamah, Enih ; Purwatiningsih, Sri ; Kuspradini, Harlinda ; Syafrizal ; Astuti, Juli ; Kim, Yong Ung ; Shimizu, Kuniyoshi. / Antidermatophyte and antimelanogenesis compound from Eleutherine americana grown in Indonesia. In: Journal of Natural Medicines. 2010 ; Vol. 64, No. 2. pp. 223-226.
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