Antidiabetic, tyrosinase inhibitory, and free radical scavenging activities of the purified extracts from Morinda citrifolia unripe fruits

Jintana Masoongnoen, Sompong Sansenya, Kongaphisith Tongpoolsomjit, Jarupa Viyoch, Kanokorn Wechakorn

Research output: Contribution to journalArticlepeer-review

Abstract

The crude extracts from medicinal plants are increasingly important for bioactive activities. Several parts of Morinda citrifolia have been utilized in traditional medicine, such as diabetes, anticancer, and hypertension. Therefore, the purpose of this research was to investigate the biological activities, e.g., antioxidant, antidiabetic, and tyrosinase inhibitory activity of the crude extracts of Morinda citrifolia unripe fruits. The highest percent extraction was found in methanol. The purified methanoic fraction displayed the highest total phenolic content and was a potent tyrosinase inhibitor. The fraction of ethyl acetate exhibited the highest flavonoid content and DPPH free radical scavenging capacity. Furthermore, the ethyl acetate and methanol fractions were investigated as potent a-glucosidase and a-amylase inhibitors. Additionally, the cytotoxicity test of the bioactive fractions was explored in human keratinocyte cell lines.

Original languageEnglish
Pages (from-to)735-743
Number of pages9
JournalSongklanakarin Journal of Science and Technology
Volume44
Issue number3
Publication statusPublished - May 1 2022
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

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