Antifungal Steroid Saponins from Dioscorea cayenensis

M. Sautour, A. C. Mitaine-Offer, Tomofumi Miyamoto, A. Dongmo, M. A. Lacaille-Dubois

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

From the rhizomes of Dioscorea cayenensis Lam.-Holl (Dioscoreaceae), the new 26-O-β-D-glucopyranosyl-22-methoxy-3β,26-dihydroxy-25(R)-furost-5- en-3-O-α-L-rhamnopyranosyl-(1 →4)-α-L-rhamnopyranosyl-(1 →4)-[α-L-rhamnopyranosyl-(1 →2)]-β-D-glucopyranoside (1) was isolated together with the known dioscin (2) and diosgenin 3-O-α-L-rhamnopyranosyl-(1 →4)-α-L-rhamnopyranosyl-(1 →4)-[α-L-rhamnopyranosyl-(1 →2)]-β-D-glucopyranoside (3). Their structures were established on the basis of spectral data. Compound 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 12.5, 12.5 and 25 μg/mL, respectively) whereas 3 showed weak activity and 1 was inactive.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalPlanta Medica
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

Fingerprint

Diosgenin
Dioscorea
Rhizome
Candida
Saponins
Candida albicans
Human Activities
Yeast
Yeasts
Steroids
dioscin

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Sautour, M., Mitaine-Offer, A. C., Miyamoto, T., Dongmo, A., & Lacaille-Dubois, M. A. (2004). Antifungal Steroid Saponins from Dioscorea cayenensis. Planta Medica, 70(1), 90-92. https://doi.org/10.1055/s-2004-815467

Antifungal Steroid Saponins from Dioscorea cayenensis. / Sautour, M.; Mitaine-Offer, A. C.; Miyamoto, Tomofumi; Dongmo, A.; Lacaille-Dubois, M. A.

In: Planta Medica, Vol. 70, No. 1, 01.01.2004, p. 90-92.

Research output: Contribution to journalArticle

Sautour, M, Mitaine-Offer, AC, Miyamoto, T, Dongmo, A & Lacaille-Dubois, MA 2004, 'Antifungal Steroid Saponins from Dioscorea cayenensis', Planta Medica, vol. 70, no. 1, pp. 90-92. https://doi.org/10.1055/s-2004-815467
Sautour M, Mitaine-Offer AC, Miyamoto T, Dongmo A, Lacaille-Dubois MA. Antifungal Steroid Saponins from Dioscorea cayenensis. Planta Medica. 2004 Jan 1;70(1):90-92. https://doi.org/10.1055/s-2004-815467
Sautour, M. ; Mitaine-Offer, A. C. ; Miyamoto, Tomofumi ; Dongmo, A. ; Lacaille-Dubois, M. A. / Antifungal Steroid Saponins from Dioscorea cayenensis. In: Planta Medica. 2004 ; Vol. 70, No. 1. pp. 90-92.
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