Antifungal Steroid Saponins from Dioscorea cayenensis

M. Sautour, A. C. Mitaine-Offer, T. Miyamoto, A. Dongmo, M. A. Lacaille-Dubois

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)

Abstract

From the rhizomes of Dioscorea cayenensis Lam.-Holl (Dioscoreaceae), the new 26-O-β-D-glucopyranosyl-22-methoxy-3β,26-dihydroxy-25(R)-furost-5- en-3-O-α-L-rhamnopyranosyl-(1 →4)-α-L-rhamnopyranosyl-(1 →4)-[α-L-rhamnopyranosyl-(1 →2)]-β-D-glucopyranoside (1) was isolated together with the known dioscin (2) and diosgenin 3-O-α-L-rhamnopyranosyl-(1 →4)-α-L-rhamnopyranosyl-(1 →4)-[α-L-rhamnopyranosyl-(1 →2)]-β-D-glucopyranoside (3). Their structures were established on the basis of spectral data. Compound 2 exhibited antifungal activity against the human pathogenic yeasts Candida albicans, C. glabrata and C. tropicalis (MICs of 12.5, 12.5 and 25 μg/mL, respectively) whereas 3 showed weak activity and 1 was inactive.

Original languageEnglish
Pages (from-to)90-92
Number of pages3
JournalPlanta medica
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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