Antigen-specific augmentation factor involved in murine delayed-type footpad reaction.III.Genetic restriction of delayed hypersensitivity augmentation factor (DAF)

Akira Yamada, Kunisuke Himeno, Seiji Nakamura, Kikuo Nomoto

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1 Citation (Scopus)

Abstract

We found an antigen-specific factor capable of augmenting delayed-type hypersensitivity (DTH) in the culture supernatant of the mixture of immune T cells and specific antigen, or in the serum of mice immunized with xenogeneic erythrocytes and elicited for DTH footpad reaction.Previous experiments on the genetic restriction of this factor (DTH-augmentation factor; DAF) indicated that DAF activity was effective across the MHC-barrier in OH/He (H-2 k ) - BALB/c (H-2 d ) system.The genetic restriction between DAF and its acceptor cells was then investigated precisely using Igh (immunoglobulin heavy chain locus)-congeneic mice: 1) Expression of DAF activity was MHC-nonrestricted, 2) but was restricted by the Ighlinked gene on the 12th chromosome, 3) such Igh-linked gene restriction was also demonstrated by an absorption test with normal spleen cells.The acceptor cells for DAF were Thy-1 + , L3T4 + , Lyt-2 T cells.

Original languageEnglish
Pages (from-to)24-34
Number of pages11
JournalImmunobiology
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jan 1 1987

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Hematology

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