Antimicrobial and anti-oxidative activities of 12-arylbenzoacridines

Boonsong Wungsintaweekul, Kayoko Abe, Rintaro Koga, Yoshinori Katakura, Kohei Torikai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines.

Original languageEnglish
Pages (from-to)1199-1205
Number of pages7
JournalIndonesian Journal of Chemistry
Volume20
Issue number5
DOIs
Publication statusPublished - 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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