TY - JOUR
T1 - Antimicrobial and anti-oxidative activities of 12-arylbenzoacridines
AU - Wungsintaweekul, Boonsong
AU - Abe, Kayoko
AU - Koga, Rintaro
AU - Katakura, Yoshinori
AU - Torikai, Kohei
N1 - Funding Information:
This work was partially supported by a grant from the Fukuoka Foundation for Sound Health (to K.T.). B.W. and K.T. thank the financial support by Walailak University for inviting K.T. to Walailak University to start this collaboration. We thank Mr. Peter Hall, who teaches at Hiramatsu Educational Group, Oita, Japan, for his English proofreading. This paper is dedicated to Prof. Hiroshi Noguchi in Nihon Pharmaceutical University, Japan, on the occasion of his 70th birthday.
Publisher Copyright:
© 2020, Gadjah Mada University. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines.
AB - Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines.
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U2 - 10.22146/ijc.53411
DO - 10.22146/ijc.53411
M3 - Article
AN - SCOPUS:85086013970
SN - 1411-9420
VL - 20
SP - 1199
EP - 1205
JO - Indonesian Journal of Chemistry
JF - Indonesian Journal of Chemistry
IS - 5
ER -