Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis

Yoshihiro Iwamoto, Fusanori Nishimura, Yoshihiko Soga, Kazu Takeuchi, Mikinao Kurihara, Shogo Takashiba, Yoji Murayama

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Background: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-α (TNF-α) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-α levels. Methods: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-α levels were measured. Results: Both CRP and TNF-α levels were significantly decreased after treatment (P <0.01 and P <0.03, respectively), while adiponectin levels did not change significantly. Conclusions: Periodontal treatment is effective in reducing CRP and TNF-α, while adiponectin does not appear to be influenced by periodontal treatment. Elevated levels of CRP and TNF-α may be associated with increased risk for future development of atherosclerosis in periodontitis patients.

Original languageEnglish
Pages (from-to)1231-1236
Number of pages6
JournalJournal of periodontology
Volume74
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

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Chronic Periodontitis
Adiponectin
C-Reactive Protein
Blood Proteins
Tumor Necrosis Factor-alpha
Atherosclerosis
Therapeutics
Periodontitis
Calculi
Periodontal Diseases
Debridement
Anti-Bacterial Agents

All Science Journal Classification (ASJC) codes

  • Periodontics

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Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. / Iwamoto, Yoshihiro; Nishimura, Fusanori; Soga, Yoshihiko; Takeuchi, Kazu; Kurihara, Mikinao; Takashiba, Shogo; Murayama, Yoji.

In: Journal of periodontology, Vol. 74, No. 8, 01.08.2003, p. 1231-1236.

Research output: Contribution to journalArticle

Iwamoto, Yoshihiro ; Nishimura, Fusanori ; Soga, Yoshihiko ; Takeuchi, Kazu ; Kurihara, Mikinao ; Takashiba, Shogo ; Murayama, Yoji. / Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. In: Journal of periodontology. 2003 ; Vol. 74, No. 8. pp. 1231-1236.
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AU - Takeuchi, Kazu

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AU - Takashiba, Shogo

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N2 - Background: Elevated levels of C-reactive protein (CRP) and decreased plasma adiponectin are associated with increased risk of atherosclerosis. Furthermore, recent observations suggested that adiponectin and tumor necrosis factor-α (TNF-α) suppressed each other's production. Since periodontal disease has been suggested to act as a risk factor for atherosclerosis, we examined the effects of antimicrobial periodontal treatment on CRP, adiponectin, and TNF-α levels. Methods: Fifteen chronic periodontitis patients with various systemic conditions at high risk for atherosclerosis were enrolled in the study. Patients were non-surgically treated with topical application of antibiotics and mechanical debridement of calculus once a week for 1 month. Before and after therapy, CRP, adiponectin, and TNF-α levels were measured. Results: Both CRP and TNF-α levels were significantly decreased after treatment (P <0.01 and P <0.03, respectively), while adiponectin levels did not change significantly. Conclusions: Periodontal treatment is effective in reducing CRP and TNF-α, while adiponectin does not appear to be influenced by periodontal treatment. Elevated levels of CRP and TNF-α may be associated with increased risk for future development of atherosclerosis in periodontitis patients.

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