Antioxidant and anti-lipase compounds isolated from heartwood of Yakushima native cedar (Cryptomeria japonica)

Toshinori Nakagawa, Ahmed Ashour, Yhiya Amen, Koichiro Ohnuki, Noboru Fujimoto, Kuniyoshi Shimizu

Research output: Contribution to journalArticle

Abstract

This article describes the biological activities of heartwood extracts from Yakushima native cedar (Cryptomeria japonica) and identifies their main active compounds. Black heartwood and red heartwood were each divided into two parts from the center (the pith) to outer heartwood (the cambium). The methanol extracts of those parts were screened for antioxidant and anti-lipase activities. The extract from the pith of the red heartwood showed the highest ORAC activity among the samples. Regarding anti-lipase activity, all the extracts showed relatively high activity (the IC 50 value were 9.71–37.24 μg mL −1 ). In addition, four compounds were isolated and identified from the pith of red heartwood by NMR and MS analyses. Agatharesinol (3) and sequirin C (4) were thought to be the main active compounds responsible for the antioxidant and anti-lipase activities.

Original languageEnglish
JournalJournal of Wood Chemistry and Technology
DOIs
Publication statusPublished - Jan 1 2019

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Lipases
Antioxidants
Lipase
Bioactivity
Methanol
Nuclear magnetic resonance

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Science(all)

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Antioxidant and anti-lipase compounds isolated from heartwood of Yakushima native cedar (Cryptomeria japonica). / Nakagawa, Toshinori; Ashour, Ahmed; Amen, Yhiya; Ohnuki, Koichiro; Fujimoto, Noboru; Shimizu, Kuniyoshi.

In: Journal of Wood Chemistry and Technology, 01.01.2019.

Research output: Contribution to journalArticle

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