Antioxidant Houttuynia cordata extract upregulates filaggrin expression in an aryl hydrocarbon-dependent manner

Kazuko Doi, Chikage Mitoma, Takeshi Nakahara, Uchi Hiroshi, Akiko Hashimoto-Hachiya, Masakazu Takahara, Gaku Tsuji, Makiko Nakahara, Masutaka Furue

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The plant Houttuynia cordata, which is called "dokudami" in Japanese, is known as a potent antioxidant herb that has been traditionally consumed as a folk medicine for various ailments, such as diabetes, obesity, cough, fever and skin diseases, in Asia. However, its antioxidant mechanism remains largely unknown. In the present study, we investigated the effects of Houttuynia cordata extract (HCE) on human keratinocytes. HCE activated aryl hydrocarbon receptor (AHR) and nuclear factor E2-related factor 2, with subsequent induction of the antioxidative enzyme NAD (P)H: quinone oxidoreductase 1 gene. HCE inhibited the generation of reactive oxygen species (ROS) in keratinocytes stimulated with tumor necrosis factor α or benzo(α)pyrene. Moreover, HCE upregulated the gene expression of filaggrin, an essential skin barrier protein, in an AHR-dependent manner. HCE may be beneficial for treating ROS-related photoaging and barrier-disrupted skin conditions.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalFukuoka igaku zasshi = Hukuoka acta medica
Volume105
Issue number11
Publication statusPublished - Nov 1 2014

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Hydrocarbons
Up-Regulation
Antioxidants
Houttuynia
Aryl Hydrocarbon Receptors
Keratinocytes
Reactive Oxygen Species
NF-E2-Related Factor 2
Skin
Enzyme Induction
Traditional Medicine
Skin Diseases
Cough
NAD
Oxidoreductases
Fever
Tumor Necrosis Factor-alpha
Obesity
filaggrin
Houttuynia cordata plant extract

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Antioxidant Houttuynia cordata extract upregulates filaggrin expression in an aryl hydrocarbon-dependent manner. / Doi, Kazuko; Mitoma, Chikage; Nakahara, Takeshi; Hiroshi, Uchi; Hashimoto-Hachiya, Akiko; Takahara, Masakazu; Tsuji, Gaku; Nakahara, Makiko; Furue, Masutaka.

In: Fukuoka igaku zasshi = Hukuoka acta medica, Vol. 105, No. 11, 01.11.2014, p. 205-213.

Research output: Contribution to journalArticle

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AU - Hiroshi, Uchi

AU - Hashimoto-Hachiya, Akiko

AU - Takahara, Masakazu

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