Antioxidants for healthy skin: The emerging role of aryl hydrocarbon receptors and nuclear factor-erythroid 2-related factor-2

Masutaka Furue, Uchi Hiroshi, Chikage Mitoma, Akiko Hashimoto-Hachiya, Takahito Chiba, Takamichi Ito, Takeshi Nakahara, Gaku Tsuji

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Skin is the outermost part of the body and is, thus, inevitably exposed to UV rays and environmental pollutants. Oxidative stress by these hazardous factors accelerates skin aging and induces skin inflammation and carcinogenesis. Aryl hydrocarbon receptors (AHRs) are chemical sensors that are abundantly expressed in epidermal keratinocytes and mediate the production of reactive oxygen species. To neutralize or minimize oxidative stress, the keratinocytes also express nuclear factor-erythroid 2-related factor-2 (NRF2), which is a master switch for antioxidant signaling. Notably, there is fine-tuned crosstalk between AHR and NRF2, which mutually increase or decrease their activation states. Many NRF2-mediated antioxidant phytochemicals are capable of up- and downmodulating AHR signaling. The precise mechanisms by which these phytochemicals differentially affect the AHR and NRF2 system remain largely unknown and warrant future investigation.

Original languageEnglish
Article number223
JournalNutrients
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 3 2017

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Aryl Hydrocarbon Receptors
hydrocarbons
Antioxidants
antioxidants
Skin
receptors
keratinocytes
Phytochemicals
Keratinocytes
phytopharmaceuticals
Oxidative Stress
oxidative stress
Skin Aging
Environmental Pollutants
Human Body
carcinogenesis
ultraviolet radiation
reactive oxygen species
Reactive Oxygen Species
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Antioxidants for healthy skin : The emerging role of aryl hydrocarbon receptors and nuclear factor-erythroid 2-related factor-2. / Furue, Masutaka; Hiroshi, Uchi; Mitoma, Chikage; Hashimoto-Hachiya, Akiko; Chiba, Takahito; Ito, Takamichi; Nakahara, Takeshi; Tsuji, Gaku.

In: Nutrients, Vol. 9, No. 3, 223, 03.03.2017.

Research output: Contribution to journalReview article

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