Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain

Eiji Suzuki, Toshio Nakaki, Futoshi Shintani, Shigenobu Kanba, Hitoshi Miyaoka

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nitric oxide synthase inhibitors have been regarded as potentially beneficial for psychiatric disorders such as depression and schizophrenia, though little is known about how nitric oxide synthases are affected by psychotropic drugs in the brain. Using reverse transcription-polymerase chain reaction analysis, we investigated the effects of short- and long-term oral treatments with several psychotropics on type II nitric oxide synthase gene expression in the rat brain. With maprotiline and fluvoxamine, enzyme mRNA levels were higher after a 28 day treatment than after 1 and 4 day treatments. Zonisamide, carbamazepine and diazepam also increased mRNA, though differences in levels between 1, 4 and 28 day treatments were not significant. These results suggest that psychotropics modulate the gene expression of type-II nitric oxide synthase in the brain.

Original languageEnglish
Pages (from-to)217-219
Number of pages3
JournalNeuroscience Letters
Volume333
Issue number3
DOIs
Publication statusPublished - Nov 29 2002

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Anti-Anxiety Agents
Nitric Oxide Synthase Type II
Anticonvulsants
Antidepressive Agents
Antipsychotic Agents
zonisamide
Nitric Oxide Synthase
Messenger RNA
Brain
Maprotiline
Fluvoxamine
Gene Expression
Psychotropic Drugs
Carbamazepine
Diazepam
Reverse Transcription
Psychiatry
Schizophrenia
Depression
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain. / Suzuki, Eiji; Nakaki, Toshio; Shintani, Futoshi; Kanba, Shigenobu; Miyaoka, Hitoshi.

In: Neuroscience Letters, Vol. 333, No. 3, 29.11.2002, p. 217-219.

Research output: Contribution to journalArticle

Suzuki, Eiji ; Nakaki, Toshio ; Shintani, Futoshi ; Kanba, Shigenobu ; Miyaoka, Hitoshi. / Antipsychotic, antidepressant, anxiolytic, and anticonvulsant drugs induce type II nitric oxide synthase mRNA in rat brain. In: Neuroscience Letters. 2002 ; Vol. 333, No. 3. pp. 217-219.
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